167081-37-0

Basic information

• Product Name: TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE
• Synonyms: trans-1-(Boc-aMino)-3-(hy...;trans-1-(Boc-aMino)-3-(hydroxyMethyl)cyclobutane;trans-3-(Boc-aMino)cyclobutaneMethanol, 97%;BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;tert-Butyl (trans-3-(hydroxymethyl);TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;Carbamic acid, [3-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester, trans-;tert-butyl N-[trans-3-(hydroxymethyl)cyclobutyl]carbamate
• CAS NO: 167081-37-0
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26
• Product Categories: N-BOC
• Mol File: 167081-37-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 317.9°C at 760 mmHg
• Flash Point: 146.1°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 3.11E-05mmHg at 25°C
• Refractive Index: 1.486
• PKA: 12.42±0.40(Predicted)
• CAS DataBase Reference: TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE(167081-37-0)
• EPA Substance Registry System: TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE(167081-37-0)

Safety Data

• Hazardous Substances Data: 167081-37-0(Hazardous Substances Data)

Usage

General Description

Tert-Butyl trans-3-hydroxymethylcyclobutylcarbamate is a chemical compound that is commonly used as a protecting group in organic synthesis. It is a derivative of trans-3-hydroxymethylcyclobutylcarbamate, with a tert-butyl group attached to the nitrogen atom. TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE is often used to protect the hydroxyl group of alcohols and phenols during chemical reactions, as it can be easily removed under mild conditions. It is also used in the pharmaceutical industry as a building block for the synthesis of various drugs. Tert-Butyl trans-3-hydroxymethylcyclobutylcarbamate is considered a versatile and important chemical reagent in organic chemistry.

InChI:InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-8-4-7(5-8)6-12/h7-8,12H,4-6H2,1-3H3,(H,11,13)/t7-,8-

Upstream product

• 1101173-77-6 (1s,3s)-methyl 3-((tert-butoxycarbonyl)amino)cyclobutane-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1101173-77-6 methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate 
• 62184-63-8 cyclobutane-1,3-dicarboxylic acid 
• 98277-66-8 bicyclo[3.1.1]heptane-2,4-dione 
• 1401103-71-6 cis-3-(methoxycarbonyl)cyclobutanecarboxylic acid 
• 50-00-0 formaldehyd 
• 1389264-12-3 tert-butyl N-(3-iodocyclobutyl)carbamate 
• 946152-72-3 3-{[(tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid 
• 695-95-4 methyl 3-oxocyclobutanecarboxylate 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 1101173-77-6 methyl 3-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate 
• 142733-63-9 cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate 

Downstream Products

• 871014-28-7 tert-butyl ((cis)-3-(aminomethyl)cyclobutyl)carbamate 
• 171549-91-0 tert-butyl N-(trans-3-formylcyclobutyl)carbamate 
• 171549-91-0 tert-butyl N-(cis-3-formylcyclobutyl)carbamate 
• 171549-91-0 trans-(3-formyl-cyclobutyl)-carbamic acid tert-butyl ester 
• 142733-65-1 cis-(3-aminocyclobutyl)methanol hydrochloride 

Relevant articles and documents

BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

?-LACTAMASE INHIBITOR AND USE THEREOF

Provided are a β-lactamase inhibitor of formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof, and a method of preparing the same. Further provided is a pharmaceutical composition comprising the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for treating diseases caused by bacterial infection, which comprises administering the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or the pharmaceutically acceptable salt thereof to a patient or a subject in need.

Indoleamine-2,3-dioxygenase inhibitor as well as preparation method and application thereof

The invention provides a compound as shown in a formula (I). The invention also relates to a pharmaceutical composition containing the compound of the formula (I) and application of the compound to preparation of an indoleamine-2,3-dioxygenase (IDO) inhibitor drug. The compound prepared by the method of the invention has an obvious inhibiting effect on IDO protease and is stable in metabolism in vivo. The compound or a pharmaceutical composition thereof provided by the invention can be used for preparing the IDO inhibitor drug, and can also be used for preparing medicines for preventing and/ortreating diseases with pathological characteristics of an IDO-mediated tryptophan metabolic pathway.