167081-41-6

Basic information

• Product Name: Carbamic acid, [(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester (9CI);3-[(Boc-amino)methyl]-cyclobutanol
• CAS NO: 167081-41-6
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26276
• Product Categories: N-BOC
• Mol File: 167081-41-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 319.9°C at 760 mmHg
• Flash Point: 147.3°C
• Appearance: /
• Density: 1.094g/cm³
• Vapor Pressure: 2.68E-05mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Carbamic acid, [(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester (9CI)(167081-41-6)
• EPA Substance Registry System: Carbamic acid, [(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester (9CI)(167081-41-6)

Safety Data

• Hazardous Substances Data: 167081-41-6(Hazardous Substances Data)

Usage

Uses

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate is used as a reactant in the preparation of isoquinolinone and quinazolinone derivatives as MDM2 and MDM4 inhibitors, useful in treatment of diseases.

InChI:InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-6-7-4-8(12)5-7/h7-8,12H,4-6H2,1-3H3,(H,11,13)

Upstream product

• 167081-42-7 3-(aminomethyl)cyclobutanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Ornithine decarboxylase inhibiting cyclic aminooxy compounds

Compounds of formula (I): H2 N--(CH2)n --A--(CH2)m --O--NH2 and salts thereof are described in which the radical A is C3 -C6 cycloalkylene; n is 0 or 1 and, independen