167101-22-6Relevant academic research and scientific papers
A relay route for the synthesis of azadirachtin
Veitch, Gemma E.,Beckmann, Edith,Burke, Brenda J.,Boyer, Alistair,Ayats, Carles,Ley, Steven V.
, p. 7633 - 7635 (2007)
(Chemical Equation Presented) 22 Years in the making: Azadirachtin (1) was synthesized for the first time by a highly convergent approach, utilizing a Claisen rearrangement and a radical cyclization as key steps. End-game strategies relied on intermediate 2, which could be obtained by synthetic methods as well as by degradation of 1. Bn = benzyl, TBS = tert- butyldimethylsilyl.
Chemistry of Insect Antifeedants from Azadirachta Indica (Part 19): A Potential Relay Route for the Synthesis of Azadirachtin.
Denholm, Alastair A.,Jennens, Lyn,Ley, Steven V.,Wood, Anthony
, p. 6591 - 6604 (2007/10/02)
A potential relay route for the synthesis of azadirachtin (1) has been established.An advanced intermediate 4 has been prepared and methods to convert this back to the natural product has been developed, in particular, the reintroduction of the enol double bond using an acetal exchange process.
