167106-58-3Relevant academic research and scientific papers
Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation
Satheesha Rai,Kalluraya, Balakrishna,Lingappa,Shenoy, Shaliny,Puranic, Vedavati G.
, p. 1715 - 1720 (2008/12/20)
Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
Reactions of 3-substituted-4-amino-5-mercapto-1,2,4-triazoles with acetylenic ketones and α-bromochalcones
Kalluraya, Balakrishna,D'Suoza, Alphonsus,Holla, B. Shivarama
, p. 1017 - 1022 (2007/10/02)
The acetylenic ketones (3) have been condensed with 3-substituted-4-amino-5-mercapto-1,2,4-triazoles (5) in ethanol to give the Michael adducts (6), which on treatment with conc.H2SO4 yield 6-aryl-8-(5-nitro-2-thienyl)-1,2,4-triazolo-1,3,4-thiadiazepines (7) whose structures have been established on the basis of analytical and spectral data.Thiadiazepines (7) are also synthesized from the reaction of α-bromochalcones (4) with triazoles (5) using sodium acetate as catalyst.However, the chalcone dibromides (2) on treatment with triazoles (5) in the presence of triethylamine undergo debromination to give the corresponding chalcones (1).
