16711-18-5Relevant academic research and scientific papers
Catalytic asymmetric conjugate addition of thiols to α,β- unsaturated thioamides: Expeditious access to enantioenriched 1,5-benzothiazepines
Ogawa, Takanori,Kumagai, Naoya,Shibasaki, Masakatsu
, p. 8551 - 8554 (2012/09/21)
Softly does it: The title reaction proceeded under proton transfer conditions with a catalyst prepared from commercially available reagents to afford the desired product in high enantioselectivity. The reaction was compatible with a free amino group, thus allowing for expeditious access to enantiomerically enriched 1,5-benzothiazepines, which are important chemical entities in medicinal chemistry.
