16715-88-1Relevant articles and documents
Method for synthesizing 4-(4-hydroxyphenyl) cyclohexanone
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Paragraph 0024; 0025; 0026, (2017/07/20)
The invention belongs to the technical field of electronic material intermediate, and discloses a method for synthesizing 4-(4-hydroxyphenyl) cyclohexanone. The method comprises the following steps: reducing 4,4'-diphenol with Al-Ni to prepare 4-(4-cyclohexanamide)-phenol; then preparing 4-(4-benzyloxy-benzene) cyclohexanol with benzyl chloride protection; oxidizing with chromium trioxide to obtain 4-(4-benzyloxy-benzene) cyclohexanone; and finally hydrogenating with 5% Pd/C to obtain 4-(4-hydroxyphenyl) cyclohexanone having a molecular formula of C12H14O2. The 4-(4-hydroxyphenyl) cyclohexanone prepared by the method is an electronic material and medicinal intermediate; and the synthesizing method has the advantages of reasonable process design, high yield and short production cycle, is economical and feasible, and easily realizes industrial production.
Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439
Lau, Shing-Hing,Galván, Alicia,Merchant, Rohan R.,Battilocchio, Claudio,Souto, José A.,Berry, Malcolm B.,Ley, Steven V.
supporting information, p. 3218 - 3221 (2015/07/15)
An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that we
Preparation process of 4-(4-hydroxyphenyl)-cyclohexanol
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, (2008/06/13)
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