16715-88-1Relevant academic research and scientific papers
Method for synthesizing 4-(4-hydroxyphenyl) cyclohexanone
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Paragraph 0024; 0025; 0026, (2017/07/20)
The invention belongs to the technical field of electronic material intermediate, and discloses a method for synthesizing 4-(4-hydroxyphenyl) cyclohexanone. The method comprises the following steps: reducing 4,4'-diphenol with Al-Ni to prepare 4-(4-cyclohexanamide)-phenol; then preparing 4-(4-benzyloxy-benzene) cyclohexanol with benzyl chloride protection; oxidizing with chromium trioxide to obtain 4-(4-benzyloxy-benzene) cyclohexanone; and finally hydrogenating with 5% Pd/C to obtain 4-(4-hydroxyphenyl) cyclohexanone having a molecular formula of C12H14O2. The 4-(4-hydroxyphenyl) cyclohexanone prepared by the method is an electronic material and medicinal intermediate; and the synthesizing method has the advantages of reasonable process design, high yield and short production cycle, is economical and feasible, and easily realizes industrial production.
Method for synthesizing 4-(4'-hydroxy phenyl) cyclohexanone
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Paragraph 0001-0005, (2017/06/24)
According to the background: 4-(4'-hydroxy phenyl) cyclohexanone is an important liquid crystal monomer, a medicine intermediate, a chemical raw material intermediate, a macromolecule intermediate, an antioxidant and the like. Along with rapid development of the crystal liquid and medicine industries in recent years, the demand on 4-(4'-hydroxy phenyl) cyclohexanone (I) is greatly increased; because of palladium-charcoal hydrogenation, a conventional process generally has defects of being large in environment pollution, poor in selectivity, low in yield, high in cost and the like. Aiming at the problems, the invention provides a novel process to solve the problems. Key points of the novel process are that firstly, an aluminum-nickel alloy is adopted to replace palladium of a heavy metal catalyst, so that pollution caused by heavy metals can be avoided; secondly, the cis/trans-selectivity can be up to 70%, the total yield can be up to 50%, the yield of a product is increased to a very large extent, and the production cost can be lowered.
Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439
Lau, Shing-Hing,Galván, Alicia,Merchant, Rohan R.,Battilocchio, Claudio,Souto, José A.,Berry, Malcolm B.,Ley, Steven V.
supporting information, p. 3218 - 3221 (2015/07/15)
An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that we
METHOD FOR PRODUCING HYDROXYPHENYLCYCLOHEXANOL COMPOUND
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Paragraph 0050, (2015/03/16)
A method comprising a step of stirring a composition containing a biphenol compound represented by the formula (1): wherein, R1 and R2 represent each independently an alkyl group having 1 to 3 carbon atoms, and m and n represent each independently an integer of 0 to 2, a secondary alcohol and a nickel catalyst, for producing a hydroxyphenylcyclohexanol compound represented by the formula (2): wherein, R1, R2, m and n represent the same meaning as described above, with the proviso that the above-described secondary alcohol has a different structure from that of the hydroxyphenylcyclohexanol compound represented by the above-described formula (2).
Preparation process of 4-(4-hydroxyphenyl)-cyclohexanol
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, (2008/06/13)
This invention relates to a novel preparation process of 4-(4-hydroxyphenyl)-cyclohexanol, which comprises subjecting 4-(4-hydroxphenyl)-3-cyclohexen-1-ol to reduction. 4-(4-Hydroxyphenyl)-cyclohexanol is a compound useful as a monomer for liquid crystall
