167159-94-6Relevant academic research and scientific papers
Novel multidrug resistance reversal agents
Berger, Dan,Citarella, Ron,Dutia, Minu,Greenberger, Lee,Hallett, William,Paul, Rolf,Powell, Dennis
, p. 2145 - 2161 (1999)
A series of 59 α-aryl-α-thioether-alkyl, -alkanenitrile, and - alkanecarboxylic acid methyl ester tetrahydroisoquinoline and isoindoline derivatives (15a-48) were synthesized and evaluated as multidrug resistance (MDR) reversal agents. The compounds were
Palladium-catalyzed C-H alkenylation of arenes using thioethers as directing groups
Yu, Ming,Xie, Yongju,Xie, Chunsong,Zhang, Yuhong
supporting information; experimental part, p. 2164 - 2167 (2012/07/16)
Thioethers have been proven to be reliable directing groups for palladium catalyzed alkenylation of arenes via C-H activation. Mechanistic investigation reveals that the C-H cleavage of arenes is the turnover-limiting step, and an acetate-bridged dinuclear cyclopalladation intermediate is involved. The alkenylated thioethers can be easily removed and transformed into a variety of useful groups.
