167165-56-2Relevant academic research and scientific papers
Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors
Goswami, Rajeev,Wohlfahrt, Gerd,T?rm?kangas, Olli,Moilanen, Anu,Lakshminarasimhan, Anirudha,Nagaraj, Jwala,Arumugam, Karthikeyan N.,Mukherjee, Subhendu,Chacko, Anita R.,Krishnamurthy, Narasimha R.,Jaleel, Mahaboobi,Palakurthy, Rajendra K.,Samiulla, Dodheri S.,Ramachandra, Murali
, p. 5309 - 5314 (2015)
Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and known to be involved in the progression of metastasis. Here we report a structure-guided approach, which resulted in the discovery of 2-aryl/pyridin-2-yl-1H-indole deri
A new chiral multidentate ligand for asymmetric catalysis
Kless, Achim,Kadyrov, Renat,Boerner, Armin,Holz, Jens,Kagan, Henri B.
, p. 4601 - 4602 (1995)
The synthesis of enantiomerically pure (R,R)-N,N'-bis(3-diphenylphosphino-2-hydroxybenzylidene)-1,2-diphenyl- 1,2-ethanediamine (1) is described. This multidentate salentype ligand offers several possibilities for the construction of chiral mono-nuclear o
INHIBITORS OF TRYPTASE
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Page/Page column 152, (2008/06/13)
The present invention related to certain inhibitors of tryptase that are inhibitors of tryptase, pharmaceutical composition comprising these compounds and method of treating asthma, allergic rhinitis, and/or Chronic Obstructive Pulmonary Disease utilizing these compounds.
Efforts toward oral bioavailability in factor VIIa inhibitors
Vijaykumar, Dange,Rai, Roopa,Shaghafi, Michael,Ton, Tony,Torkelson, Steve,Leahy, Ellen M.,Riggs, Jennifer R.,Hu, Huiyong,Sprengeler, Paul A.,Shrader, William D.,O'Bryan, Colin,Cabuslay, Ronnell,Sanford, Ellen,Gjerstadt, Erik,Liu, Liang,Sukbuntherng, Juthamas,Young, Wendy B.
, p. 3829 - 3832 (2007/10/03)
Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in improved physicochemical properties, leading to enhanced oral absorption in rat.
2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS
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Page 72, (2008/06/13)
The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
