167173-85-5

Basic information

• Product Name: UK 2A
• Synonyms: UK 2A;(3S,6S,7R,8R)-3-[[(3-Hydroxy-4-methoxy-2-pyridinyl)carbonyl]amino]-6-methyl-4,9-dioxo-8-(phenylmethyl)-1,5-dioxonan-7-yl 2-methylpropanoate;Antibiotic UK 2A
• CAS NO: 167173-85-5
• Molecular Formula: C₂₆H₃₀N₂O₉
• Molecular Weight: 514.5244
• Mol File: 167173-85-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: UK 2A(CAS DataBase Reference)
• NIST Chemistry Reference: UK 2A(167173-85-5)
• EPA Substance Registry System: UK 2A(167173-85-5)

Safety Data

• Hazardous Substances Data: 167173-85-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
UK 2A is used as an antifungal agent for its potent antifungal properties. It is particularly effective against various fungal infections, providing a valuable treatment option for patients suffering from such conditions.
Used in Agricultural Industry:
In agriculture, UK 2A is used as a fungicide to protect crops from fungal infections, ensuring higher crop yields and reduced losses due to disease.
Used in Cosmetics Industry:
UK 2A is used as an active ingredient in antifungal creams and lotions for the treatment of skin conditions caused by fungal infections, such as athlete's foot and ringworm.
Used in Research and Development:
UK 2A is utilized in research and development for the study of its antifungal properties and potential applications in various fields, including medicine, agriculture, and cosmetics.

Upstream product

• 215798-00-8 (3S,6S,7R,8R)-8-benzyl-3-[(tert-butoxycarbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate 
• 210300-12-2 (2R,3R,4S)-2-benzyl-4-((2S)-2-tert-butoxycarbonylamino-3-hydroxypropionyloxy)-3-(tert-butyldimethylsilanyloxy)-pentanoic acid 
• 210300-13-3 [(3S,7R,8R,9S)-7-benzyl-8-(tert-butyldimethylsilanyloxy)-9-methyl-2,6-dioxo-[1,5]dioxonane-3-yl]-carbamic acid tert-butyl ester 
• 215798-09-7 (2R,3R,4S)-2-benzyl-3-(tert-butyldimethylsilanyloxy)-4-(4-methoxybenzyloxy)-pentanoic acid benzyl ester 
• 210300-10-0 (4R)-[(2R,3R,4S)-2-benzyl-3-hydroxy-4-(4-methoxybenzyloxy)-pentanoyl]-4-isopropyl-oxazolidin-2-one 
• 215798-10-0 ((3S,7R,8R,9S)-7-benzyl-8-hydroxy-9-methyl-2,6-dioxo-[1,5]dioxonane-3-yl)-carbamic acid tert-butyl ester 
• 210300-11-1 (2R,3R,4S)-2-benzyl-3-hydroxy-4-(4-methoxybenzyloxy)-pentanoic acid benzyl ester 
• 210300-08-6 (2R,3R,4S)-2-benzyl-3-(tert-butyldimethylsilanyloxy)-4-hydroxypentanoic acid benzyl ester 
• 215798-08-6 (2R,3R,4S)-2-benzyl-3-hydroxy-4-(4-methoxybenzyloxy)-pentanoic acid 
• 210300-15-5 4-methoxy-3-methoxymethoxypyridine 
• 215798-03-1 (2R,3R,4S)-2-benzyl-4-((2S)-3-benzyloxy-2-tert-butoxycarbonylaminopropionyloxy)-3-(tert-butyldimethylsilanyloxy)-pentanoic acid benzyl ester 
• 645-45-4 hydrocinnamic acid chloride 
• 96837-44-4 (R)-4-isopropyl-3-(3-phenylpropanoyl)oxazolidin-2-one 
• 210300-09-7 3-hydroxy-4-methoxy-pyridine-2-carboxylic acid 

Downstream Products

• 186528-21-2 (3R,4R,5S)-3-benzyl-4-hydroxy-5-methyldihydrofuran-2(3H)-one 
• 220437-84-3 methyl-(3,4-dimethoxypicolinyl)serine 
• 517875-34-2 2-methylpropanoic acid [[4-methoxy-2-[[[(3S,7R,8R,9S)-9-methyl-8-(2-methyl-1-oxopropoxy)-2,6-dioxo-7-(phenylmethyl)-1,5-dioxonan-3-yl]amino]carbonyl]-3-pyridinyl]oxy]methyl ester 
• 215798-00-8 (3S,6S,7R,8R)-8-benzyl-3-[(tert-butoxycarbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate 
• 210300-07-5 isobutyric acid (3S,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester 
• 234113-27-0 Isobutyric acid (3S,6S,7R,8R)-8-(4-amino-benzyl)-3-[(3-hydroxy-4-methoxy-pyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester 

Relevant articles and documents

Total synthesis of the antifungal dilactones UK-2A and UK-3A: The determination of their relative and absolute configurations, analog synthesis and antifungal activities

The synthesis of the antifungal dilactones, UK-2A and UK-3A, is described. In addition to providing a workable synthetic route to these potent antifungal antibiotics, this has allowed us to determine the assignment of the relative and absolute configurations in the nine-membered ring. Furthermore, UK-2A analogs were also synthesized and evaluated their antifungal activities and cytotoxic activities along with UK-2A, (2R, 3R, 4S, 7R)-UK-2A, UK-3A, (2R, 3R, 4S, 7R)-UK-3A, and antimycin A. The structural requirements for the selective cytotoxicity against yeasts and filamentous fungi will also be suggested.

Enantioselective total synthesis of the antifungal dilactone, UK-2A: The determination of the relative and absolute configurations

The synthesis of the antifungal dilactone, UK-2A, is described. In addition to providing a workable synthetic route to this potent antifungal antibiotic, this has allowed us to determine the assignment of the relative and absolute configurations in the nine-membered ring.