16718-42-6

Basic information

• Product Name: 4,5,6-TRIMETHOXY-INDANONE
• Synonyms: 4,5,6-TRIMETHOXY-INDANONE;4,5,6-TRIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE;4,5,6-TRIMETHOXY-2,3-DIHYDROINDEN-1-ONE
• CAS NO: 16718-42-6
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 16718-42-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4,5,6-TRIMETHOXY-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6-TRIMETHOXY-INDANONE(16718-42-6)
• EPA Substance Registry System: 4,5,6-TRIMETHOXY-INDANONE(16718-42-6)

Safety Data

• Hazardous Substances Data: 16718-42-6(Hazardous Substances Data)

Usage

General Description

4,5,6-TRIMETHOXY-INDANONE is a chemical compound with the molecular formula C13H16O4. It is a white crystalline solid that is used in the production of various pharmaceuticals and fragrance products. 4,5,6-TRIMETHOXY-INDANONE has a unique aromatic smell and is commonly used as a flavoring agent in the food industry. Additionally, 4,5,6-TRIMETHOXY-INDANONE has potential applications in the synthesis of new organic compounds for medicinal and industrial purposes. Due to its versatile properties, this chemical has become a valuable reagent in organic chemistry laboratories and is the subject of ongoing research for its potential uses in various fields.

Upstream product

• 33130-03-9 3-(2,3,4-trimethoxyphenyl)acrylic acid 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 116406-19-0 trans-2,3,4-trimethoxycinnamic acid 
• 33130-04-0 3-(2,3,4-trimethoxy-phenyl)-propionic acid 
• 2680-03-7 N,N-Dimethylacrylamide 
• 634-36-6 1,2,3-trimethoxybenzene 

Downstream Products

• 890309-54-3 (+/-)-4,5,6-trimethoxy-N-((S)-1-phenethyl)-2,3-dihydroindene-1-carboxamide 
• 890309-56-5 (S)-(-)-N-(((S)-4,5,6-trimethoxyindan-1-yl)methyl)-1-phenethylamine 
• 890309-53-2 4,5,6-trimethoxyindan-1-carboxylic acid 
• 890309-51-0 C-(4,5,6-trimethoxy-indan-1-yl)-methylamine 
• 890309-51-0 C-(4,5,6-trimethoxyindan-1-yl)methanamine 
• 890309-52-1 4,5,6-trimethoxy-3H-indene-1-carbonitrile 
• 111859-48-4 2-bromo-4,5,6-trimethoxy-indan-1-one 
• 858226-08-1 4,5,6-trimethoxy-1-oxo-indan-2-carbonitrile 

Relevant articles and documents

N,N-dimethylacrylamide-triflic anhydride complex as a novel bifunctional electrophile in reaction with electron-rich aromatics

The reaction of N,N-dimethylacrylamide/trifluoromethanesulfonic anhydride complex with alkoxybenzenes followed by hydrolysis leads to the corresponding indan-1-ones and 1,3-diarylpropan-1-ones. Substituted naphthalenes yield dihydrophenalen-1-ones. Fused ring aromatics afford aromatic amines.

Synthesis, biological evaluation and mechanism study of chalcone analogues as novel anti-cancer agents

A series of novel chalcone analogues were designed, synthesized and evaluated as anticancer agents. The results of antiproliferative activity tests showed that most of the analogues exhibited moderate to very good antiproliferative activities with GI50 values in the micromol to sub-micromol range. Especially compound 10a gave 0.026 μM to 0.035 μM GI50 for five cancer cell lines. The mechanistic studies including tubulin polymerization inhibition, disruption of microtubule dynamics and cell cycle arrest assay demonstrated that compound 10a could effectively inhibit in vitro cellular tubulin polymerization, interfere with the mitosis, resulting in a prolonged G2/M cell cycle arrest and ultimately lead to cell apoptosis of cancer cells. Taken together, these results suggested that 10a may became a promising lead compound for development of new anticancer drugs.

Efficient Method for Preparing Functionalized Benzosuberenes

The disclosed process can efficiently synthesize functionalized benzosuberenes. The process provides an improved method of production of benzosuberene and compounds containing a benzosuberene moiety, which is characterized by a ring closing methodology comprising reaction of a 5-phenylpentanoic acid with Eaton's reagent to form the benzosuberone. The process, optionally, further includes steps for adding a functional group at the ketone position.