16722-09-1Relevant articles and documents
Kinetics of Iron(III) Porphyrin Catalyzed Epoxidations
Traylor, Teddy G.,Marsters, James C.,Nakano, Taku,Dunlap, Beth E.
, p. 5537 - 5539 (1985)
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Method for synthesizing 2-phenyl-2-trimethylsilyl acetyl chloride from trimethyl (vinyl) silane
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Paragraph 0008-0010, (2018/05/01)
The invention relates to a method for synthesizing 2-phenyl-2-trimethylsilyl acetyl chloride from trimethyl (vinyl) silane, to mainly solve the technical problem that an industrial synthesis method ofthe compound is in shortage. The method comprises the following three steps: step 1, dissolving trimethyl(vinyl)silane in dichloromethane, and adding 3-chloroperoxybenzoic acid at a low temperature for reaction to obtain trimethyl (2-epoxyethyl)silane; step 2, dissolving phenyl magnesium bromide and cuprous cyanide in isopropyl ether at a low temperature, and adding trimethyl(2-epoxyethyl)silanefor reaction to generate 2-phenyl-2-trimethylsilyl ethanol; step 3, carrying out a reaction of a tetrahydrofuran solution of the 2-phenyl-2-trimethylsilyl ethanol under the condition with triethylamine and triphosgene to generate 2-phenyl-2-trimethylsilyl acetyl chloride.
The (2-Phenyl-2-trimethylsilyl)ethyl-(PTMSEL)-Linker in the Synthesis of Glycopeptide Partial Structures of Complex Cell Surface Glycoproteins
Wagner, Michael,Dziadek, Sebastian,Kunz, Horst
, p. 6018 - 6030 (2007/10/03)
The (2-phenyl-2-trimethylsilyl)ethyl-(PTMSEL) linker represents a novel fluoride-sensitive anchor for the solid-phase synthesis of protected peptides and glycopeptides. Its cleavage is achieved under almost neutral conditions using tetrabutylammonium fluo