16726-82-2

Usage

Structure

Quaternary ammonium salt 2-(4-nitrobenzyl)isoquinolinium is a quaternary ammonium salt, which means it has a central nitrogen atom with four organic groups attached, giving it a positive charge.

Isoquinoline ring

Core structure The core structure of 2-(4-nitrobenzyl)isoquinolinium is an isoquinoline ring, which is a tricyclic aromatic compound with two benzene rings fused to a six-membered nitrogen-containing ring.

4-Nitrobenzyl group

Attached functional group A 4-nitrobenzyl group is attached to the isoquinoline ring, which consists of a benzene ring with a nitrogen-oxygen bond (nitro group) at the 4-position.

Fluorescent probe

Biochemical research application 2-(4-nitrobenzyl)isoquinolinium is used as a fluorescent probe to study biomolecular interactions and membrane dynamics, allowing researchers to observe and analyze the behavior of molecules within living cells.

Ligand

Pharmacology application In pharmacology, 2-(4-nitrobenzyl)isoquinolinium serves as a ligand for studying the structure and function of various biological targets, such as receptors and transport proteins, by binding to and modulating their activity.

Upstream product

• 119-65-3 isoquinoline 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 1268825-46-2 8-(4-nitrophenyl)benz[5,6]isoindolo[1,2-a]isoquinoline-9,14-dione 
• 1373764-26-1 1-((4-isopropylphenyl)(2-(4-nitrobenzyl )isoquinolinium-4-yl)methyl)-4,4-dimethyl-2,6-dioxocyclohexan-1-ide 
• 1373764-28-3 1-((3-chlorophenyl)(2-(4-nitrobenzyl)isoquinolinium-4-yl)methyl)-4,4-dimethyl-2,6-dioxocyclohexan-1-ide 
• 1373764-25-0 1-((4-methoxyphenyl)(2-(4-nitrobenzyl)isoquinolinium-4-yl)methyl)-4,4-dimethyl-2,6-dioxocyclohexan-1-ide 
• 1373764-29-4 1-((4-fluorophenyl)(2-(4-nitrobenzyl)isoquinolinium-4-yl)methyl)-4,4-dimethyl-2,6-dioxocyclohexan-1-ide 
• 1373764-24-9 4,4-dimethyl-1-((2-(4-nitrobenzyl)isoquinolinium-4-yl)(p-tolyl)methyl)-2,6-dioxocyclohexan-1-ide 
• 1373764-27-2 1-((4-tert-butylphenyl)(2-(4-nitrobenzyl )isoquinolinium-4-yl)methyl)-4,4-dimethyl-2,6-dioxocyclohexan-1-ide 
• 1373764-40-9 1,3-dimethyl-5-((2-(4-nitrobenzyl)isoquinolinium-4-yl)(phenyl)methyl)-2,4,6-trioxohexahydropyrimidin-5-ide 
• 1373764-42-1 5-((4-chlorophenyl)(2-(4-nitrobenzyl)isoquinolinium-4-yl)methyl)-1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-ide 
• 1373764-41-0 1,3-dimethyl-5-((2-(4-nitrobenzyl)isoquinolinium-4-yl)(p-tolyl)methyl)-2,4,6-trioxohexahydropyrimidin-5-ide 
• 1373764-35-2 5-((2-(4-nitrobenzyl)isoquinolinium-4-yl)(phenyl)methyl)-2,4,6-trioxohexahydropyrimidin-5-ide 
• 1373764-39-6 5-((2-(4-nitrobenzyl)isoquinolinium-4-yl)(3-nitrophenyl)methyl)-2,4,6-trioxohexahydropyrimidin-5-ide 
• 1373764-37-4 5-((4-chlorophenyl)(2-(4-nitrobenzyl)isoquinolinium-4-yl)methyl)-2,4,6-trioxohexahydropyrimidin-5-ide 

Relevant academic research and scientific papers

One-pot synthesis of 4-substituted isoquinolinium zwitterionic salts by metal-free C-H bond activation

The unprecedented isoquinolinium zwitterionic salts with an unusual C-4 substitution pattern were efficiently prepared via the multicomponent reaction of in situ formed N-benzylisoquinolinium bromide with aromatic aldehydes and cyclic 1,3-dicarbonyl compo

A one-pot domino reaction for the synthesis of 3-arylindolizines from pyridines, benzyl halides, and dihalide-substituted electron-deficient alkenes

3-Arylindolizines were prepared by one-pot domino reactions from benzyl halides with pyridine (or isoquinoline) and cyclic or acyclic dihalide-substituted electron-deficient alkenes in the presence of potassium carbonate via in situ generated N-ylide intermediate. Both electron-donating and electron-withdrawing groups are tolerated in the aryl ring of benzyl halides. The yields range from moderate to high. Georg Thieme Verlag Stuttgart - New York.

A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process

A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their

Comparative Study of Reactions of 2-Benzylisoquinolinium and 3,4-Dihydro-2-benzylisoquinolinium Salts with Carbon Disulfide in Two Base-Solvent Environments

3,4-Dihydro-2-(p-nitrobenzyl)isoquinolinium bromide (9a) reacts with carbon disulfide in both aqueous hydroxide-dioxane and triethylamine-pyridine to afford the expected 5,6-dihydro-3-(p-nitrophenyl)thiazoloisoquinolinium-2-thiolate (12) and a new