167264-38-2Relevant academic research and scientific papers
Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A
Lee, Hee-Yoon,Jung, Yongsik,Kim, Wonyeob,Kim, Jin Hee,Suh, Min-Soo,Shin, Seung Koo,Yoon, Hye-Joo
scheme or table, p. 4670 - 4674 (2009/04/08)
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established.
Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720
Matsumoto, Norimasa,Kohno, Takeyuki,Uchida, Shuji,Shimizu, Takaaki,Kusumoto, Haruko,Hirose, Ryoji,Yanada, Kazuo,Kurio, Wasako,Yamaguchi, Shoji,Watabe, Kazuhito,Fujita, Tetsuro
, p. 4182 - 4192 (2007/10/03)
FTY720 (1) is a novel immunosuppressant (immunomodulator), derived from ISP-I (2: myriocin and thermozymocidin). To clarify the pharmacokinetic properties of 1, antibodies against 1 were prepared and a competitive enzyme immunoassay (EIA) was developed. T
Antibody against a novel, myriocin (ISP-I)-based immunosuppressant, FTY720
Fujita, Tetsuro,Matsumoto, Norimasa,Uchida, Shuji,Kohno, Takeyuki,Shimizu, Takaaki,Hirose, Ryoji,Yanada, Kazuo,Kurio, Wasako,Watabe, Kazuhito
, p. 337 - 339 (2007/10/03)
An antibody was prepared by immunizing rabbits with an ovalbumin conjugate of 2-amino-2-(2-(4-(4-mercaptobutyl)-phenyl)ethyl)propane-1,3-diol HCl (AMPD-4), which contains the essential structure of the novel immunosuppressant FTY720. As the antibody react
1-(2-BENZIMIDAZOLYL)-1,5-DIAZACYCLOOCTANE COMPOUNDS
-
, (2008/06/13)
1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds represented by the formula: STR1 wherein X represents a hydrogen atom or a halogen atom; Y represents a covalent bond, a straight-or branched-chain alkylene group having 1 to 6 carbon atoms, or a straight-or branched-chain alkenylene group having 2 to 6 carbon atoms; R represents a hydrogen atom, or a straight-or branched-chain alkyl group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The compounds represented above are novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
