167282-22-6

Upstream product

• 67473-43-2 3-(dimethyl(phenyl)silyl)butanoic acid ethyl ester 
• 3839-31-4 dimethyl(phenyl)silyl lithium 
• 123-73-9 trans-Crotonaldehyde 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 123-73-9 crotonaldehyde 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 768-33-2 phenyldimethylsilyl chloride 

Downstream Products

• 1283095-90-8 (R)-2-((R)-1-(dimethyl(phenyl)silyl)ethyl)-4,4-bis(phenylsulfonyl)butanal 
• 191917-30-3 2-[3-(Dimethyl-phenyl-silanyl)-butylidene]-malonic acid dimethyl ester 
• 191916-88-8 (Z)-5-(Dimethyl-phenyl-silanyl)-hex-2-enoic acid methyl ester 
• 191916-72-0 (E)-5-(Dimethyl-phenyl-silanyl)-hex-2-enoic acid methyl ester 
• 120196-04-5 (2RS,4SR)-4-dimethyl(phenyl)silylpentan-2-ol 
• 120196-04-5 (2RS,4RS)-4-dimethyl(phenyl)silylpentan-2-ol 
• 454-57-9 fluorodimethylphenylsilane 

Relevant academic research and scientific papers

CuI-catalyzed conjugate addition of silyl boronic esters: Retracing catalytic cycles using isolated copper and boron enolate intermediates

Copper(I)-catalyzed conjugate additions of silyl boronic esters to α,β-unsaturated aldehydes, ketones, and esters are synthetically well-established reactions. For the first time central reactive intermediates as well as the boron enolates as the primary

[(18-C-6)K][(NC)CuI-SiMe2Ph], a Potassium Silylcyanocuprate as a Catalyst Model for Silylation Reactions with Silylboranes: Syntheses, Structures, and Catalytic Properties

CuI-catalyzed silylation reactions involving silylboranes (in particular, pinB-SiMe2Ph (1)) as silyl sources have recently gained considerable attention. One of the most efficient and versatile and yet simplest catalyst systems consi

Copper(II)-catalyzed silyl conjugate addition to α,β-unsaturated conjugated compounds: Bronsted base-assisted activation of Si-b bond in water

A mild method for the installation of the dimethylphenylsilyl group on the β-carbon of electron-deficient olefins is reported. In the presence of a catalytic amount of copper(II) (1 mol %) and amine base (5 mol %) at rt, the transformation proceeds effici

Access to high levels of molecular complexity by one-pot iridium/enamine asymmetric catalysis

(Chemical Equation Presented) Independent workers with team spirit: A catalytic sequence that exploits the compatibility of (chiral) cationic iridium catalysts for the isomerization of primary allylic alcohols to aldehydes with organo-catalysts has been d

Conjugate additions of a simple monosilylcopper reagent with use of the CuI-DMS complex: Stereoselectivities and a dramatic impact by DMS

(Chemical Equation Presented) Conjugate additions utilizing the simple monosilylcuprate reagent Li[PhMe2SiCuI] to α,β-unsaturated carbonyl compounds are described. The presence of dimethyl sulfide (DMS), either as a component originating from t

Copper-catalyzed conjugate addition of a bis(triorganosilyl) zinc and a methyl(triorganosilyl) magnesium

A practical copper-catalyzed conjugate silylation of α,β- unsaturated carbonyl compounds 4 utilizing bis(triorganosilyl) zinc reagent 3 is described. Moreover, mixed methyl(triorganosilyl) magnesium 7 also transfers its silyl ligand to simple enones 4 und

Employing the simple monosilylcopper reagent, Li[PhMe2SiCuI], in 1,4-addition reactions

Conjugate addition reactions using the simple Li[PhMe2SiCuI] reagent to a variety of α,β-unsaturated carbonyl compounds is described; dimethyl sulfide from the purification of CuI plays a key role for very high yields as well as high stereosele

A synthesis of enantiomerically enriched propargyl silanes

Reduction of ethyl 3-methyl-, 3-isopropyl- and 3-n-pentyl-3-[dimethyl(phenyl)silyl]propanoates 4 with DIBAL to the aldehydes 5, enol trifluoromethanesulfonate (triflate) formation using trifluoromethanesulfonic (triflic) anhydride and 2,6-di-tert-butylpyridine, and elimination using LDA, gives the propargyl silanes 8. The esters 4 could also be prepared enantiomerically enriched (11), and the final products are the enantiomerically enriched propargyl (homochiral) silanes 14.

In search of open-chain 1,3-stereocontrol

Methylation of methyl 4-phenylpentanoate 25 gives the diastereoisomers methyl (2RS,4SR)-2-methyl-4-phenylpentanoate 26 and methyl (2RS,4RS)- 2-methyl-4-phenylpentanoate 27 in a ratio of 44:56. The aldehydes 3-dimethyl(phenyl)silylbutanal 28, 3-dimethyl(ph