167371-46-2Relevant academic research and scientific papers
Synthesis and structure-activity relationship of a new series of potent angiotensin II receptor antagonists: Pyrazolo[1,5-α]pyrimidine derivatives
Shiota, Takeshi,Yamamori, Teruo,Sakai, Katsunori,Kiyokawa, Mitsugu,Honma, Tsunetoshi,Ogawa, Masayoshi,Hayashi, Kunio,Ishizuka, Natsuki,Matsumura, Ken-Ichi,Hara, Mariko,Fujimoto, Masafumi,Kawabata, Tomoji,Nakajima, Shigeyuki
, p. 928 - 938 (2007/10/03)
We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-α]pyrimidine-3- carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement of t
FUSED PYRIMIDINE COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
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, (2008/06/13)
Pharmaceutical compounds which are azolo-fused pyrimidine compounds having the formula STR1 in which =A--B--together with the pyrimidine ring forms a) a pyrazolo[1,5-a]pyrimidine of formula (A), STR2 b) a [1,2,4]triazolo[1,5-a]pyrimidine of formula (B), STR3 c) an imidazo[1,5-a]pyrimidine of formula (C), STR4 or d) an imidazo[1, 2-a]pyrimidine of formula (D), STR5
