167374-83-6Relevant academic research and scientific papers
A novel trifluoromethanesulfonamidophenyl-substituted quinoline derivative, GA 0113: Synthesis and pharmacological profiles
Morizawa, Yoshitomi,Okazoe, Takashi,Wang, Shu-Zhong,Sasaki, Jun,Ebisu, Hajime,Nishikawa, Masakuni,Shinyama, Hiroshi
, p. 83 - 86 (2007/10/03)
The trifluoromethanesulfonamidophenyl-substituted quinoline GA 0113 have been synthesized from o-nitrobenzoyl chloride via a multi-step process. GA 0113 displaced specific binding of [125I]-Sar1, Ile8-Ang II to AT1 receptors in membrane from Sf9 cells. In concious normotensive dogs, GA 0113 inhibited the Ang II-induced pressor response with ID50 of 0.032mg/kg and dose-dependently increased plasma renin activity for 48h.
