16738-20-8

Basic information

• Product Name: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA
• Synonyms: (2,4-xylyl)thiourea;2,4-xylylthiourea;2-thio-1-(2,4-xylyl)-ure;2-thio-1-(2,4-xylyl)urea;2,4-DIMETHYLPHENYLTHIOUREA;1-(2,4-DIMETHYLPHENYL)-2-THIOUREA;AKOS BBS-00000747;1-(2,4-Dimethylphenyl)thiourea
• CAS NO: 16738-20-8
• Molecular Formula: C₉H₁₂N₂S
• Molecular Weight: 180.27
• EINECS: -0
• Mol File: 16738-20-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 177-179°C
• Boiling Point: 290.7°Cat760mmHg
• Flash Point: 129.6°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.00203mmHg at 25°C
• Refractive Index: 1.674
• PKA: 13.40±0.70(Predicted)
• BRN: 2639862
• CAS DataBase Reference: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA(16738-20-8)
• EPA Substance Registry System: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA(16738-20-8)

Safety Data

• Statements: 25
• Safety Statements: 22-36/37-45
• RIDADR: 2811
• RTECS: YU3675000
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 16738-20-8(Hazardous Substances Data)

Usage

Uses

(2,4-Dimethylphenyl)thiourea

InChI:InChI=1/C9H12N2S/c1-6-3-4-8(7(2)5-6)11-9(10)12/h3-5H,1-2H3,(H3,10,11,12)

Upstream product

• 39842-01-8 2,4-dimethylphenylisothiocyanate 
• 95-68-1 2,4-Xylidine 
• 1147550-11-5 ammonium thiocyanate 
• 56615-73-7 C₆H₁₅N*C₉H₁₁NS₂ 
• 83697-77-2 N-(2,4-dimethylphenyl)-N′-benzoylthiourea 
• 21436-96-4 2,4-xylidine hydrochloride 

Downstream Products

• 133890-02-5 4,6-diamino-1-(2,4-dimethylphenyl)-2(1H)-pyrimidinethione 
• 1267448-30-5 6,8-dimethyl-4-phenyl-2H-pyrimido[2,1-b]benzothiazol-2-one 
• 2990-02-5 1-(2,4-dimethylphenyl)urea 
• 2295-31-0 thiazoline-2,4-dione 
• 71018-87-6 1-(2,4-dimethylphenyl)-5-methyl-tetrahydro-s-triazin-2[1H]-thione 
• 119155-49-6 N-(2,4-Dimethyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 119155-48-5 N-(2,4-Dimethyl-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 
• 94646-85-2 1-(2,4-Dimethyl-phenyl)-2-methyl-isothiourea; hydriodide 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nau

Cobalt-promoted one-pot reaction of isothiocyanates toward the synthesis of aryl/alkylcyanamides and substituted tetrazoles

[Figure not available: see fulltext.] The synthesis of cyanamides and tetrazoles from isothiocyanates through tandem reaction using cobalt catalyst has been demonstrated. In the case of tetrazole preparation, the reaction involved addition/desulfurization/nucleophilic addition/electrocyclization, whereas aromatic cyanamides were constructed from isothiocyanates through addition/desulfurization. Cheap cobalt sulfate was used for the synthesis of various cyanamides and tetrazoles. In addition, cobalt catalyst was found to be desulfurization reagent that has not been previously reported. The final products have been obtained from starting precursors in good to high yield.