Cas 167403-79-4,4-tert-Butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzenesulfonamide

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Check Digit Verification of cas no

The CAS Registry Mumber 167403-79-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,4,0 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 167403-79:
(8*1)+(7*6)+(6*7)+(5*4)+(4*0)+(3*3)+(2*7)+(1*9)=144
144 % 10 = 4
So 167403-79-4 is a valid CAS Registry Number.

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167403-79-4Relevant academic research and scientific papers

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from Bosentan

Neidhart, Werner,Breu, Volker,Burri, Kaspar,Clozel, Martine,Hirth, Georges,Klinkhammer, Uwe,Giller, Thomas,Ramuz, Henri

, p. 2223 - 2228 (2007/10/03)

Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows affinities for ET(A) and ET(B) receptors in the low nanomolar range and high functional antagonistic potency in vitro.

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