167422-88-0Relevant academic research and scientific papers
Construction of an all-carbon quaternary stereocenter by the peptide-catalyzed asymmetric michael addition of nitromethane to β-disubstituted α,β-unsaturated aldehydes
Akagawa, Kengo,Kudo, Kazuaki
, p. 12786 - 12789 (2013/02/22)
Pepping up Michael: An asymmetric Michael addition of nitromethane to β-disubstituted α,β-unsaturated aldehydes was realized by a resin-supported peptide catalyst. Whereas the use of a low-molecular-weight catalyst resulted in poor yields, the peptide effectively promoted the reaction in aqueous media with high enantioselectivity. Copyright
Enantioselective synthesis of nitroalkanes bearing all-carbon quaternary stereogenic centers through Cu-catalyzed asymmetric conjugate additions
Wu, Jing,Mampreian, Dawn M.,Hoveyda, Amir H.
, p. 4584 - 4585 (2007/10/03)
The first examples of catalytic asymmetric conjugate addition (ACA) of alkylzinc reagents to trisubstituted nitroalkenes, leading to the formation of nitroalkanes bearing a quaternary carbon stereogenic center, are reported. Reactions are promoted in the
Enantioselective Conjugate Addition of Primary Dialkylzinc Reagents to 2-Aryl- and 2-Heteroaryl-nitroolefins Mediated by Titanium-TADDOLates Preparation of Enantioenriched 2-Aryl-alkylamines
Schaefer, Harald,Seebach, Dieter
, p. 2305 - 2324 (2007/10/02)
The addition of dialkylzinc to nitroolefins is catalyzed by Lewis acids such as MgBr2, MgI2, and chlorotitanates.Using the (R,R)-Ti-TADDOLates the addition of diethyl-, dibutyl-, and dioctyl zinc to 2-aryl-nitroethenes is shown to be enantioselective with
