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16748-29-1

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16748-29-1 Usage

General Description

N-Alpha-methyl-L-ornithine hydrochloride is a chemical compound that is used in scientific research and pharmaceutical development. It is a derivative of the amino acid ornithine and is often used as an inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. By blocking this enzyme, N-alpha-methyl-L-ornithine hydrochloride can help regulate the production of polyamines, which are important for cell growth and proliferation. N-ALPHA-METHYL-L-ORNITHINE HYDROCHLORIDE has shown potential in cancer treatment research, as well as in the study of various metabolic and neurological disorders. Additionally, it has been investigated for its potential use in preventing tropical diseases such as African sleeping sickness.

Check Digit Verification of cas no

The CAS Registry Mumber 16748-29-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,4 and 8 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16748-29:
(7*1)+(6*6)+(5*7)+(4*4)+(3*8)+(2*2)+(1*9)=131
131 % 10 = 1
So 16748-29-1 is a valid CAS Registry Number.

16748-29-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-5-amino-2-(methylamino)pentanoic acid

1.2 Other means of identification

Product number -
Other names N2-methyl-L-ornithine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16748-29-1 SDS

16748-29-1Downstream Products

16748-29-1Relevant articles and documents

Synthesis of cyclic and acyclic Nα-methyl-Nω-alkyl-L-arginine analogues

Kokko, Kyle P.,Hooper, H. Brooks,Dix, Thomas A.

, p. 2151 - 2153 (2004)

A series of Nα-methyl-alkyl-L-arginine (Arg) analogues have been synthesized from inexpensive, commercially available starting materials. These analogues, once incorporated into pharmaceutically relevant peptides, are expected to increase binding affinity, receptor selectivity, lipophilicity, and stability as demonstrated with analogues of similar design and structure.

AN ALTERNATIVE ROUTE TO Nα-METHYLAMINO ACID DERIVATIVES: SYNTHESIS AND CONFORMATION OF SOME Nα-acetyl-Nα-METHYLAMINO ACID METHYLAMIDES

Hlavacek, Jan,Fric, Ivo,Budesinsky, Milos,Blaha, Karel

, p. 2473 - 2494 (2007/10/02)

The methylation of tert-butyl- or isopropyl esters of Nα-4-toluenesulfonyl-amino acids by dimethylsulfate in aqueous alkaline solution in the presence of a detergent gives the corresponding Nα-methylderivatives.Using this synthetic route the Nα-acetylderivatives of MeAla, MeLeu, MeOrn and MePhe methylamides have been prepared and the solution conformation of these dipeptide units has been investigated. 1H and 13C NMR spectra show that, while in dimethylsulfoxide the tertiary amide group is mostly in cis-conformation, in protic solvents the equilibrium is shifted towards trans-conformation.Circular dichroism spectra reveal some specific features (e.g. high band intensities in protic solvents) which cannot be explained solely on the basis of the increased rigidity caused by the Nα-methyl group.We tried to explain these effects supposing that the tertiary amide group is deviated from the planar arrangement (due to the interaction between the methyl groups, a substituent on Cα and solvent molecule attached to the oxygen atom) and contributes to the observed circular dichroism as the inherently chiral chromophore.

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