167502-75-2

Upstream product

• 130854-92-1 (1S,2S)-N-(4-methylphenylsulphonyl)-2-amino-1-phenyl-1,3-propanediol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 167029-47-2 (2R,3R)-2-hydroxymethyl-1-(4-methylphenylsulfonyl)-3-phenylaziridine 
• 167613-42-5 (2R,3R)-2-(tert-butyldimethylsiloxy)methyl-3-phenyl-1-<(4-methylphenyl)sulfonyl>aziridine 

Relevant academic research and scientific papers

Solution- and solid-phase synthesis of 4-hydroxy-4,5-dihydroisoxazole serivatives from enantiomerically pure N-tosyl-2,3-aziridine alcohols

(formula presented) Enantiomerically pure N-tosyl-2,3-aziridine alcohols are directly converted into 4-hydroxy-4,5-dihydroisoxazole 2-oxides through oxidation to the corresponding aldehydes followed by in situ tandem nitroaldol-intramolecular cyclization.

Synthesis of optically pure 2-Aziridinemethanols: Versatile synthetic building blocks

Synthesis of three cis-trans pairs of N-sulfonylated-2-aziridinemethanols starting from (S)-threonine, (R)-allothreonine, a chiral 2-amino alcohol, or enantiomerically enriched 2,3-epoxy alcohols is described. A synthetic route to N-tosyl- and N-mesyl-2-a