167566-22-5

Upstream product

• 52479-85-3 2,3,4,3',4',5'-hexahydroxybenzophenone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 167566-23-6 (RS)-5-<3,5-dihydroxy-4-(2-oxo-2-phenylethoxy)>-benzoyl-3,3-bis(hydroxymethyl)-8a-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-8(8aH)-one 

Relevant academic research and scientific papers

NOVEL 1,4-BENZOXAZINE DERIVATIVES OF PHARMACOLOGICAL INTEREST. ELECTROCHEMICAL AND CHEMICAL SYNTHESES.

The reaction of electrochemically or chemically generated orthoquinones with aminoalcohols, in methanol, affords a convenient route to novel 1,4-benzoxazine derivatives.Some of these compounds are found to possess interesting pharmacological properties.

Benzoxazine derivatives, methods for obtaining same, and their use as drugs

Compounds are provided corresponding to the following general formula (I): in which:--R1 and R2, independently of each other, represent an alkyl group with 1 to 3 carbon atoms, or a group of formula --CH2 --ORa, Ra representing a hydrogen atom or a methyl group Rx represents: an alkyl group with 1 to 3 carbon atoms, in particular a methyl group, or an --ORx1 group, Rx1 representing an alkyl group with 1 to 3 carbon atoms, in particular a methoxy group, or a group of formula --CH2 --X in which X represents a halogen atom, in particular chlorine, or a group of formula (a) STR1 in which: R3 and R5, independently of each other, represent a hydrogen atom, or an --OH group, or an --OCH3 group, R4 represents a hydrogen atom, or an --ORb group, Rb representing a hydrogen atom or a methyl group, or R4 represents a group of formula --Orc, Rc representing a group of formula --CH2 --CO--C6 H4 R'. The present compounds are benzoxazine derivatives which are used for treating pathological conditions associated with the presence of free radicals, such as Alzheimer's disease, and methods are provided for preparation of these compounds.