167631-84-7

Usage

InChI:InChI=1/C10H8FNO2/c1-14-10(13)9-5-6-4-7(11)2-3-8(6)12-9/h2-5,12H,1H3

Downstream Products

• 906543-03-1 (5-fluoro-1-methyl-1H-indol-2-yl)methanol 
• 940960-54-3 2-(allyloxymethyl)-1-benzyl-5-fluoro-1H-indole 
• 940960-67-8 (E)-4-((1-benzyl-5-fluoro-1H-indol-2-yl)methoxy)but-2-enal 
• 302901-19-5 5-fluoro-1H-indole-2-carbohydrazide 
• 1374452-62-6 {4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester 
• 1374452-63-7 (1-{4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester 
• 1374452-65-9 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamine 
• 1374452-61-5 1-amino-cyclopropanecarboxylic acid 4-[5-fluoro-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-indol-1-yl]-benzylamide 
• 220943-23-7 5-fluoro-1H-indole-2-carboxaldehyde 

Relevant academic research and scientific papers

Cu(I)-catalyzed intramolecular cyclization of ene-carbamates: Synthesis of indoles and pyrrolo[2,3-c]pyridines

Over the past few years, the use of palladium-catalyzed aromatic carbon-nitrogen bond forming reactions by the cross-coupling of aryl halides or triflates and amines has become a useful synthetic tool. Herein, we describe a copper(I) catalyst system that allows efficient synthesis of functionalized indoles and pyrrolo[2,3-c]pyridines. This method takes advantage of amino acid promoted copper coupling of amines with aryl halides, in particular, the use of the CuI/l-proline catalyst system.