167708-35-2Relevant academic research and scientific papers
Condensed isoquinolines. 9. Alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones
Kisel',Potikha,Kovtunenko
, p. 560 - 568 (2000)
The alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one proceeds at N(6) or C(7) depending on the type of alkylating agent and reaction conditions. C(7)-Alkylation occurs in the presence of base. The secondary alkylation of the 7-alkyl derivatives occurs at the same position under these conditions. Depending on the conditions, the reaction with o-xylylene dibromide leads to spiro[SH-isoquino [2,3-a]quinazolin-7(12H),2′-indane]-5-one or 11-oxo-4b,5,10,16-tetrahydro-11H-10a-azonia-15b-azadibenz[a,e]pleiadene bromide, which are derivatives of new heterocyclic systems.
