167710-87-4

Basic information

• Product Name: 1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE
• Synonyms: RS 39604 HYDROCHLORIDE;1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE;1-(4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy)-3-(1-(2-methylsulfonylamino)ethyl)piperidin-4-yl)propan-1-onehyd;RS39604HCl;1-(4-Amino-5-Chloro-2-(3,5-Dimethoxyphenyl)Methyloxy)-3-(1-(2-Methylsulfonylamino)Ethyl)Piperidin-4-;1-[4-Amino-5-Chloro-2-(3,5-Dimethoxyphenyl)Methyloxy]-3-[[1-[2-Methylsulphonylamino]Ethyl]Piperidin-4-Yl]Propan-1-One Hydrochloride
• CAS NO: 167710-87-4
• Molecular Formula: C26H38Cl3N3O6S
• Molecular Weight: 627.02
• Mol File: 167710-87-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 746.9°C at 760 mmHg
• Flash Point: 405.5°C
• Appearance: /
• Vapor Pressure: 1.25E-22mmHg at 25°C
• Storage Temp.: Store at RT
• CAS DataBase Reference: 1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE(167710-87-4)
• EPA Substance Registry System: 1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE(167710-87-4)

Safety Data

• Hazardous Substances Data: 167710-87-4(Hazardous Substances Data)

Usage

Uses

RS 39604 Hydrochloride is a potent, selective and orally active 5-HT4 receptor antagonist.

Biological Activity

A potent and selective 5-HT 4 antagonist, with a pK i of 9.1 at 5-HT 4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT 1A, 2C, 3 and D 1 , D 2 , M 1 , M 2 , AT 1, B 1 and α 1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.

InChI:InChI=1/C26H36ClN3O6S.ClH/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33;/h12-16,18,29H,4-11,17,28H2,1-3H3;1H

Relevant articles and documents

1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS

The present invention relates to novel 5-HT 4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C 2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C 1-4)alkyloxy or phenyl(C 1-4)alkyloxy and optionally substituted at its 3-position with (C 1-4)alkyloxy or substituted at its 2-and 3-positions together with methylenedioxy or ethylenedioxy and the highest numbered carbon of the (C 2-6)alkan-1-one is substituted with di(C 1-4)alkylamino, morpholin-1-yl or pyrrolidin-1-yl or optionally substituted piperidin-1-yl, piperidin-4-yl, azacyclohept-1-yl, azabicyclo[2.2.1]hept-3-yl, azabicylo[2.2.2]oct-3-yl or azabicylo[3.2. 2] non-3-yl; and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers and methods of using and making such derivatives.