167756-84-5Relevant academic research and scientific papers
Isoquinolinyl compounds which are useful in treating cerebral vascular disorders
-
, (2008/06/13)
Compounds represented by the formula: STR1 wherein the ring A and the ring B each stand for an optionally substituted benzene ring; Ar stands for an optionally substituted aryl group or an optionally substituted heterocyclic group; Q stands for an oxygen atom or a sulfur atom; R stands for a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted amino group; X stands for --O-- or --NR1 -- wherein R1 stands for a hydrogen atom or an optionally substituted hydrocarbon group; Y stands for --O--, --NR2 -- wherein R2 stands for a hydrogen atom or an optionally substituted hydrocarbon group, or a bond; m denotes 1, 2 or 3, and n denotes 0, 1 or 2, and salts thereof which have excellent calcium- or substance P receptor-antagonistic activity, being useful for treating a cerebralvascular disorder in mammals such as cerebralischemia, cerebral edema and neuronal damage, their production and use.
