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CAS

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1677668-27-7

4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1677668-27-7 Structure

  • Basic information

    1. Product Name: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid
    2. Synonyms:
    3. CAS NO:1677668-27-7
    4. Molecular Formula:
    5. Molecular Weight: 433.851
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1677668-27-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid(1677668-27-7)
    11. EPA Substance Registry System: 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid(1677668-27-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1677668-27-7(Hazardous Substances Data)

1677668-27-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1677668-27-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,7,7,6,6 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1677668-27:
(9*1)+(8*6)+(7*7)+(6*7)+(5*6)+(4*6)+(3*8)+(2*2)+(1*7)=237
237 % 10 = 7
So 1677668-27-7 is a valid CAS Registry Number.

1677668-27-7Upstream product

1677668-27-7Downstream Products

1677668-27-7Relevant articles and documents

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Fauber, Benjamin P.,Gobbi, Alberto,Robarge, Kirk,Zhou, Aihe,Barnard, Adrian,Cao, Jianhua,Deng, Yuzhong,Eidenschenk, Céline,Everett, Christine,Ganguli, Arunima,Hawkins, Julie,Johnson, Adam R.,La, Hank,Norman, Maxine,Salmon, Gary,Summerhill, Susan,Ouyang, Wenjun,Tang, Wei,Wong, Harvey

, p. 2907 - 2912 (2015)

The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine interleukin-17. We discovered a series of potent and selective imidazo[1,5-a]pyridine and -pyrimidine RORc inverse agonists. The most potent compounds displayed >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs in our cellular selectivity panel. The favorable potency, selectivity, and physiochemical properties of GNE-0946 (9) and GNE-6468 (28), in addition to their potent suppression of IL-17 production in human primary cells, support their use as chemical biology tools to further explore the role of RORc in human biology.

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