167767-86-4

Upstream product

• 167767-81-9 6,7-dihydroxy-4-thiaheptanoic acid p-methoxybenzyl ester 
• 112-67-4 n-hexadecanoyl chloride 

Downstream Products

• 204582-78-5 (S)-2-{2-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 204582-76-3 (S)-2-{3-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 167767-21-7 4-[6,7-bis(palmitoyloxy)-4-thiaheptanoylaminomethyl]benzoylglutamic acid di-t-butyl ester 
• 167767-01-3 (S)-2-{4-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzenesulfonylamino}-pentanedioic acid di-tert-butyl ester 
• 167767-48-8 (S)-2-{4-[3-(2,3-Bis-hexadecanoyloxy-propane-1-sulfinyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 167767-49-9 (S)-2-{4-[3-(2,3-Bis-hexadecanoyloxy-propane-1-sulfonyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 167766-99-6 (S)-2-{4-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of TAN-1511 analogues as potent hematopoietic agents

A series of TAN-1511 analogues bearing a non-peptide spacer in place of the Gly-Gly-Gly sequence in the peptide moiety was synthesized, and the effects of these compounds on the proliferation of bone marrow cells in culture and experimental leukocytopenia in mice were examined. The structure- activity relationships obtained were as follows. As the substituent at the 2- position of the 4-thiabeptanoic acid framework, an amino group, methyl group or hydrogen was preferable; as a spacer in place of the Gly-Gly-Gly sequence, a 4-aminobenzoyl or 4-aminomethylbenzoyl group was suitable; and as the fatty acids bonded to the 6,7-dihydroxy groups, C16 fatty acid was best. Compounds 12f, 30d and 30i potently promoted the proliferation of bone marrow cells in culture and the restoration of leukocyte counts in a murine leukocytopenia model.

Thioglycerol derivatives

A compound of the invention is represented by the formula: STR1 wherein R1 and R2 are the same or different, an acyl group; R3, R4, R6 and R7 are the same or different, hydrogen or an alkyl