1678-02-0

Basic information

• Product Name: 7-Phenylbenzo[b]thiophene
• Synonyms: 7-Phenylbenzo[b]thiophene
• CAS NO: 1678-02-0
• Molecular Formula: C₁₄H₁₀S
• Molecular Weight: 210.29
• Mol File: 1678-02-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 35.5-36.5 °C
• Boiling Point: 148-150 °C(Press: 1.3 Torr)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 7-Phenylbenzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Phenylbenzo[b]thiophene(1678-02-0)
• EPA Substance Registry System: 7-Phenylbenzo[b]thiophene(1678-02-0)

Safety Data

• Hazardous Substances Data: 1678-02-0(Hazardous Substances Data)

Upstream product

• 1391861-09-8 C₂₀H₂₆OSSi 
• 121-46-0 bicyclo[2.2.1]hepta-2,5-diene 
• 318463-07-9 C₈H₄Cl₂S 
• 98-80-6 phenylboronic acid 
• 1444457-43-5 C₁₆H₁₄O₂S 

Relevant articles and documents

Pd-Catalyzed Cyclization of Alkynyl Norbornene Derivatives for the Synthesis of Benzofused Heteroarenes

Modular approaches, which allow a systematic variation of heteroaromatic cores and substituents, are crucial for the development of heteroaromatic drug candidates and organic functional materials. A new strategy involving the cyclization of heteroarenes tethered with alkynes through a norbornene bridge was developed. The precursors were readily prepared by a three-component coupling process of heteroaryl halides, norbornadiene, and terminal alkynes. The Pd catalytic system derived from Pd(OAc)2 and 2-(pyrazol-1-yl)pyridine transformed a variety of five-membered heteroarenes to the corresponding benzofused products, including (di)benzothiophene, indazole, carbazole, indole, and benzofuran, with aryl and alkyl substituents at the C4(C7) position. During the cyclization process, the norbornene ring underwent a retro-Diels-Alder reaction, serving as an acetylene synthon. This approach was used to synthesize naphthalene derivatives from electron-rich arenes, demonstrating its versatility in the annulation of (hetero)aromatic rings. (Figure presented.).

General approach to benzo[b]thiophenes, benzo[b]furans, and dibenzofurans via gold-catalyzed cyclization of 1-heteroarylalka-2,3-dienyl acetates

An efficient and mild route to a series of benzo[b]thiophenes, benzo[b]furans, and dibenzofurans through gold-catalyzed benzannulation of 1-heteroarylalka-2,3-dienyl acetates was developed. Two possible pathways of this reaction involving gold carbene and aryl gold intermediates have been proposed on the basis of mechanistic studies.