1678-06-4Relevant academic research and scientific papers
Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones
Basuli, Scuhand,Satyanarayana, Gedu
, p. 957 - 970 (2017/12/07)
Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.
Room temperature palladium-catalyzed decarboxylative ortho -acylation of acetanilides with α-oxocarboxylic acids
Fang, Ping,Li, Mingzong,Ge, Haibo
scheme or table, p. 11898 - 11899 (2010/11/02)
A novel Pd-catalyzed decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids is realized at room temperature. This reaction provides efficient access to o-acyl acetanilides under mild conditions.
