167817-55-2 Usage
Description
2-Iodo-L-Phenylalanine is a chemical compound derived from the amino acid phenylalanine, featuring an additional iodine atom that imparts unique chemical properties. 2-Iodo-L-Phenylalanine is instrumental in organic and biochemistry research, serving as a valuable tool for investigating protein structure and function.
Uses
Used in Organic Chemistry Research:
2-Iodo-L-Phenylalanine is utilized as a research tool for studying protein structure and function, enabling scientists to gain insights into the molecular mechanisms underlying various biological processes.
Used in Biochemistry Research:
In biochemistry, 2-Iodo-L-Phenylalanine is employed for labeling and tracking specific proteins within cellular environments, aiding in the understanding of protein dynamics and interactions.
Used in Pharmaceutical Development:
2-Iodo-L-Phenylalanine may have potential applications in the development of pharmaceuticals, given its unique chemical properties that could be harnessed to create novel therapeutic agents.
Used in Medical Imaging Agent Development:
2-Iodo-L-Phenylalanine also holds promise in the field of medical imaging, where it could be used to develop new agents that enhance the visualization of biological processes and structures within the body.
Overall, 2-Iodo-L-Phenylalanine plays a significant role in advancing the scientific understanding of biological processes and possesses potential practical applications across various fields, including pharmaceuticals and medical imaging.
Check Digit Verification of cas no
The CAS Registry Mumber 167817-55-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,8,1 and 7 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 167817-55:
(8*1)+(7*6)+(6*7)+(5*8)+(4*1)+(3*7)+(2*5)+(1*5)=172
172 % 10 = 2
So 167817-55-2 is a valid CAS Registry Number.
167817-55-2Relevant articles and documents
2-[ 18 F]Fluorophenylalanine: Synthesis by Nucleophilic 18 F-Fluorination and Preliminary Biological Evaluation
Modemann, Daniel J.,Zlatopolskiy, Boris D.,Urusova, Elizaveta A.,Zischler, Johannes,Craig, Austin,Ermert, Johannes,Guliyev, Mehrab,Endepols, Heike,Neumaier, Bernd
, p. 664 - 676 (2019/01/23)
2-[ 18 F]Fluorophenylalanine (2-[ 18 F]FPhe), a promising PET tracer for imaging of cerebral infarction and tumors, was efficiently prepared from an easily accessible iodonium salt precursor using Cu-mediated radiofluorination under 'low base' or 'minimalist' conditions. Whereas significant racemization was initially observed if the 'minimalist' protocol was applied for radiolabeling, it was completely suppressed by the careful adjustment of 18 F - preprocessing. The initial biological study revealed a higher uptake of 2-[ 18 F]FPhe in different tumor cells in comparison to that of [ 18 F]FET. In contrast to 4-[ 18 F]FPhe, which suffered from rapid defluorination in vivo, 2-[ 18 F]FPhe demonstrated a sufficient in vivo stability. Conclusively, 2-[ 18 F]FPhe is a promising PET probe that is now readily available using Cu-mediated radiofluorination under 'minimalist' or 'low base' conditions. The simplicity of the translation of the proposed procedures to automated synthesis modules allows a broad biological evaluation of 2-[ 18 F]FPhe. Notably, a novel protocol for the preparation of N -Boc protected amino acids from the respective Ni-Schiff base complexes was developed that avoided application of strongly acidic conditions.
