1679336-98-1

Basic information

• Product Name: 4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile
• Synonyms: 4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile;4,6-dimethyl-2-oxo-1-{[(1E)-1-(thiophen-2-yl)ethylidene]amino}-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 1679336-98-1
• Molecular Formula: C14H13N3OS
• Molecular Weight: 271.33752
• Mol File: 1679336-98-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile(1679336-98-1)
• EPA Substance Registry System: 4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile(1679336-98-1)

Safety Data

• Hazardous Substances Data: 1679336-98-1(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 88-15-3 2-Acetylthiophene 

Relevant articles and documents

Syntheses, crystal structures, in vitro antitumor and free radical scavenging activity evaluation of a series of 2-substituted thiophenes

A series of thiazole, pyridine and benzylidene derivatives derived from thiophene scaffold have been synthesized. The antitumor evaluation of the newly synthesized products against four cancer cell lines, namely breast carcinoma (MCF-7), liver carcinoma (HepG2), colon carcinoma (HCT-116) and prostate carcinoma (PC3), indicated that the thiazole derivative 11b showed remarkable activity against all cell lines with LC50 values of 18.3, 2.5, 7.5 and 7.6 μM, respectively. Cytotoxicity toward normal cell lines was also investigated and indicated that compound 21c displayed remarkable potency against PC3 with LC50 values of 7.1 μM and showed weak inhibition of normal cell lines at (GI %) of 41.2 % and thus could be considered as an important lead compound for potential application in anticancer chemotherapy. Brine shrimp lethality assay of the most active compounds was carried out to detect possible cytotoxicity effects and indicated that highly active compound, 21c, is not harmful. The X-ray crystallographic analysis of compounds 3 and 11b was obtained thus establishing with certainty the proposed structures in this work. The synthesized compounds were also screened for their free radical scavenging activity. Hydrazino-thiazole derivatives 15 and 16 showed remarkable antioxidant activity with IC50 values of 60.9 and 61.9 μg ml-1, respectively.