1680-73-5

Basic information

• Product Name: 2-Chloro-1-formyl-1-cyclohexene
• Synonyms: 2-Chloro-1-formyl-1-cyclohexene;2-Chlorocyclohex-1-enecarbaldehyde;1-Cyclohexene-1-carboxaldehyde, 2-chloro-;(2-chlorocyclohex-1-enyl)carboxaldehyde;2-chlorocyclohex-1-enylcarboxaldehyd...;2-Chloro-1-cyclohexene-1-carboxaldehyde;2-Chloro-1-cyclohexenecarboxaldehyde;2-Chloro-1-formylcyclohexene
• CAS NO: 1680-73-5
• Molecular Formula: C₇H₉ClO
• Molecular Weight: 144.59876
• Mol File: 1680-73-5.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 88-90℃ (11 Torr)
• Flash Point: 91.781 °C
• Appearance: /
• Density: 1.134 g/cm³
• Refractive Index: 1.5198 (589.3 nm 20℃)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-Chloro-1-formyl-1-cyclohexene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-1-formyl-1-cyclohexene(1680-73-5)
• EPA Substance Registry System: 2-Chloro-1-formyl-1-cyclohexene(1680-73-5)

Safety Data

• Hazardous Substances Data: 1680-73-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-1-formyl-1-cyclohexene, also known as chloroformylcyclohexene or chlorocyclohexenone, is an organic chemical compound with the molecular formula C7H9ClO. It is a colorless liquid with a molecular weight of 140.6 g/mol. 2-Chloro-1-formyl-1-cyclohexene is primarily used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used as a reagent in organic reactions, such as the synthesis of various heterocyclic compounds. Additionally, 2-Chloro-1-formyl-1-cyclohexene is a potent inhibitor of monoamine oxidase A (MAO-A) and is under investigation for potential therapeutic applications in the treatment of neurological disorders and mood disorders. Due to its potential hazardous properties, such as its irritant and toxic effects, proper handling and storage of this chemical are essential.

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 68-12-2 N,N-dimethyl-formamide 
• 108-94-1 cyclohexanone 
• 4065-81-0 cyclohexen-1-ol 
• 79-01-6 Trichloroethylene 
• 50-00-0 formaldehyd 
• 822-87-7 2-Chlorocyclohexanone 

Downstream Products

• 5632-33-7 5,6,7,8-tetrahydroquinazoline 
• 42057-99-8 2-methylselanyl-cyclohex-1-enecarbaldehyde 
• 39831-18-0 2-((Z)-3-Oxo-1,2-diphenyl-propenylsulfanyl)-cyclohex-1-enecarbaldehyde 
• 42141-25-3 2-thiocyanato-cyclohex-1-enecarbaldehyde 
• 1192-88-7 1-cyclohexene-1-carboxaldehyde 
• 35811-99-5 1,2-Di-(1-cyclohexenyl)aethylenplycol 
• 19809-85-9 di(2-formylcyclohex-1-ene)sulfide 
• 19181-36-3 1,3-Diamino-7,8,9,10-tetrahydropyrimido<4,5-c>isoquinoline 
• 120504-82-7 1-(2-Chloro-cyclohex-1-enyl)-propan-1-ol 
• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 55860-92-9 (2-methyl-1-cyclohexen-1-yl)trimethylsilane 
• 138826-05-8 1-chloro-1-(2-chloro-1-cyclohexenyl)-2,2-dimethylcyclopropane 

Relevant articles and documents

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Two-Step Synthesis of 3,4-Dihydropyrrolopyrazinones from Ketones and Piperazin-2-ones

An expedient two-step synthesis of 3,4-dihydropyrrolopyrazinones has been achieved via a Vilsmeier-Haack reaction of ketones, followed by an annulation of the corresponding chloroaldehydes with commercially available piperazin-2-ones. A variety of cyclic and acyclic ketones and piperazin-2-ones participated in this two-step chemistry, affording the desired 3,4-dihydropyrrolopyrazinones in up to 78% yield.