16805-10-0

Usage

Uses

Used in Pharmaceutical Industry:
Genistein is used as a potential therapeutic agent for the treatment of various diseases and conditions, including cancer, cardiovascular diseases, and cognitive disorders. Its anti-inflammatory and antioxidant properties contribute to its potential health benefits.
Used in Nutraceutical Industry:
Genistein is used as a dietary supplement to promote overall health and well-being. Its potential health benefits, such as reducing the risk of certain cancers, improving bone health, and alleviating menopausal symptoms, make it a popular choice for consumers seeking natural health solutions.
Used in Cosmetic Industry:
Genistein is used in cosmetic products for its antioxidant and anti-inflammatory properties, which can help protect the skin from environmental damage and promote a healthy complexion.
Used in Functional Food Industry:
Genistein is incorporated into functional foods and beverages as a natural ingredient with potential health benefits, such as reducing the risk of certain cancers, improving bone health, and alleviating menopausal symptoms.

InChI:InChI=1/C16H12O8/c1-23-16-9(19)2-6(3-10(16)20)15-14(22)13(21)12-8(18)4-7(17)5-11(12)24-15/h2-5,17-20,22H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 529-44-2 myricetin 

Relevant academic research and scientific papers

One new flavonoid xyloside and one new natural triterpene rhamnoside from the leaves of Syzygium grande

One new flavonoid glycoside, myricetin 4′-methyl ether 3-O-β-d-xylopyranoside (1) and one new natural triterpene glycoside, grandoside (2) were isolated from a MeOH extract of the leaves of Syzygium grande, together with thirteen known compounds (3-15). The structures of the new compounds were determined through a combination of spectroscopic and chemical analyses. All of the isolated compounds were evaluated for their antifungal, antibacterial, anti-leishmania, DPPH radical-scavenging and cytotoxic activities by means of MTT assay.

Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity

The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase. In most cases, flavonoids were isolated as the active constituents by bioassay-guided separation, and among them, quercitrin (IC50=0.15 μM), guaijaverin (0.18 μM), and desmanthin-1 (0.082 μM) exhibited potent inhibitory activity. Desmanthin-1 showed the most potent activity, which was equivalent to that of a commercial synthetic aldose reductase inhibitor, epalrestat (0.072 μM). In order to clarify the structural requirements of flavonoids for aldose reductase inhibitory activity, various flavonoids and related compounds were examined. The results suggested the following structural requirements of flavonoid: 1) the flavones and flavonols having the 7-hydroxyl and/or catechol moiety at the B ring (the 3′,4′-dihydroxyl moiety) exhibit the strong activity; 2) the 5-hydroxyl moiety does not affect the activity; 3) the 3-hydroxyl and 7-O-glucosyl moieties reduce the activity; 4) the 2-3 double bond enhances the activity; 5) the flavones and flavonols having the catechol moiety at the B ring exhibit stronger activity than those having the pyrogallol moiety (the 3′,4′,5′-trihydroxyl moiety).