168072-33-1

Basic information

• Product Name: 3-Pyridinecarboxaldehyde, 4-ethyl-2-methyl- (9CI)
• Synonyms: 3-Pyridinecarboxaldehyde, 4-ethyl-2-methyl- (9CI);4-Ethyl-2-Methylnicotinaldehyde
• CAS NO: 168072-33-1
• Molecular Formula: C9H11NO
• Molecular Weight: 149.18974
• Product Categories: ALDEHYDE;PYRIDINE
• Mol File: 168072-33-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 248.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.040±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.94±0.18(Predicted)
• CAS DataBase Reference: 3-Pyridinecarboxaldehyde, 4-ethyl-2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxaldehyde, 4-ethyl-2-methyl- (9CI)(168072-33-1)
• EPA Substance Registry System: 3-Pyridinecarboxaldehyde, 4-ethyl-2-methyl- (9CI)(168072-33-1)

Safety Data

• Hazardous Substances Data: 168072-33-1(Hazardous Substances Data)

Upstream product

• 1027241-62-8 4-Ethyl-2-methyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 38059-40-4 4-ethyl-2-methyl-nicotinic acid ethyl ester 
• 1576-86-9 2-pentenal 
• 1026263-17-1 (4-Ethyl-2-methyl-pyridin-3-yl)-methanol 

Downstream Products

• 1026599-91-6 3-[2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-4-ethyl-2-methyl-pyridine 
• 1026857-83-9 3-{Chloro-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-methyl}-4-ethyl-2-methyl-pyridine 

Relevant articles and documents

Nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological activity of pyridine derivatives

Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists. Substitution at the position 2 in the pyridine resulted in potent activity, and the optimal alkyl length was four carbons. The potency further increased with the introduction of a hydroxymethyl group at the position 4. One of the compounds, 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-[[2'-(1H-tetrazol-5-yl)bip henyl-4-yl]methyl]pyridine 9 h (KT3-579)is a competitive AII antagonist with a pA2 value of 9.31, and is about 10 times more potent than Du Pont 753. It was found to be an AT1 specific antagonist with an IC50 of 3.09 nM.