16808-63-2 Usage
Uses
Used in Research Applications:
(-)-NORMETAZOCINE is used as a research chemical for studying its potential as a treatment for depression and other psychiatric disorders. Its unique pharmacological properties, which are similar to both opioids and psychostimulants, make it a valuable compound for understanding the mechanisms of action and potential therapeutic applications in these areas.
However, due to its abuse potential and limited therapeutic use, (-)-NORMETAZOCINE is a highly regulated substance and is not approved for medical use in humans. Further research is needed to fully understand its safety, efficacy, and potential applications in the treatment of various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 16808-63-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,0 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16808-63:
(7*1)+(6*6)+(5*8)+(4*0)+(3*8)+(2*6)+(1*3)=122
122 % 10 = 2
So 16808-63-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3
16808-63-2Relevant academic research and scientific papers
Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides
Ramakrishnan,Portoghese
, p. 1423 - 1427 (2007/10/02)
In an effort to test the hypothesis that the tyramine moiety present in opiates and in opioid peptides plays an identical functional role at opioid receptors, a hybrid enkephalinamide (3) that contains (-)-metazocine in place of Tyr1 was synthesized. It was found that 3 and its congeners are inactive or feebly active in the electrically stimulated guinea pig ileum and mouse vas deferens preparations. The results of these studies suggest that the tyramine moiety in opiates and related structures does not play the same functional role as that in the opioid peptides. It is suggested that the different functional roles of the tyramine moiety in opiates and opioid peptides is a consequence of different modes of interaction with common receptors.
