168083-29-2Relevant academic research and scientific papers
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class
Von Sprecher, Andreas,Gerspacher, Marc,Beck, Andreas,Kimmel, Sabine,Wiestner, Hansruedi,Anderson, Gary P.,Niederhauser, Ulrich,Subramanian, Natarajan,Bray, Michael A.
, p. 965 - 970 (2007/10/03)
The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4- [3-(7-fluoro-2-quinolinylmethoxy)phenyl-amino]-2,2-diethyl-4-oxo-butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.
Quinoline compound
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, (2008/06/13)
Compounds of formula I STR1 wherein R1 -R5, X, Ar and Y are as defined in the description, have valuable pharmaceutical properties and are especially effective as leukotriene antagonists. They are prepared in a manner known per se.
