16813-38-0

Usage

Uses

Used in Cancer Treatment:
3-cyclohexyl-1-methyl-1-nitrosourea is used as an anticancer agent for its potential to target brain tumors and other solid tumors. Its alkylating properties allow it to bind to DNA and induce cell death, offering a therapeutic approach to combat cancer progression.
However, due to its known hepatotoxicity and potential harmful effects, 3-cyclohexyl-1-methyl-1-nitrosourea must be used with caution and under strict medical supervision. Further research and clinical trials are necessary to establish its efficacy and safety in cancer therapy.

Upstream product

• 39804-96-1 1-cyclohexyl-3-methylurea 
• 13120-04-2 methyl-1 cyclohexyl-3 thio-2 uree 
• 108-91-8 cyclohexylamine 
• 624-83-9 methyl isocyanate 

Downstream Products

• 99307-05-8 S-butyl cyclohexylcarbamothioate 

Relevant academic research and scientific papers

N-Nitroso Compounds. IV. Reaction of N-Nitrosourea with Thiol. A New Synthesis of Thiocarbamic S-Esters

Thirteen thiocarbamic S-esters have been prepared in good yield by the reaction of thiol with substituted N-methyl-N-nitrosourea in anhydrous acetonitrile.

Conformational Preferences in Alkylnitrosoureas

The spectroscopic properties of several N-alkyl-N-nitrosoureas, N,N'-dialkyl-N-nitrosoureas, and N,N',N'-trialkyl-N-nitrosoureas have been studied in carbon disulfide and chloroform solutions.The NH stretching frequencies in the IR spectra have been observed in both concentrated and dilute solution and in the presence of added dioxane.The results indicate that there is a strong intramolecular hydrogen bond in the mono- and dialkylnitrosoureas.The chemical shifts and line widths of the NMR spectra have also been studied in these solvents.The large chemical shift differences, about 1.3 ppm, for the NH protons in the monoalkylnitrosoureas and other spectroscopic features in the monoalkyl- and dialkylnitrosoureas also indicate that an intramolecular hydrogen bond contributes to a strong conformational preference.The temperature dependence of the NMR spectra of several N,N',N'-trialkyl-N-nitrosoureas establishes that the energy barrier for rotation about the carbon dialkylamide bond is about 13 kcal mol-1.Dipolar resonance interactions are primarily responsible for this barrier.This interaction is augmented by a strong, 8-10 kcal mol-1, hydrogen bond in the mono- and dialkylnitrosoureas.