16813-98-2Relevant academic research and scientific papers
Catalytic Alkynylation of Polyfluoroarenes by Amide Base Generated In Situ
Shigeno, Masanori,Okawa, Takuya,Imamatsu, Masaya,Nozawa-Kumada, Kanako,Kondo, Yoshinori
supporting information, p. 10294 - 10297 (2019/07/18)
We herein demonstrate that the amide base generated in situ from CsF and N(TMS)3 catalyzes the deprotonative coupling reactions of terminal alkynes with polyfluoroarenes, wherein mono- and dialkynylations occur efficiently for penta- and hexafluorobenzenes, respectively. Tetraalkynylated products could also be synthesized from dialkynylated compounds.
Transition-metal-free sonogashira-type cross-coupling of alkynes with fluoroarenes
Jin, Guanyi,Zhang, Xuxue,Cao, Song
supporting information, p. 3114 - 3117 (2013/07/26)
A novel, inexpensive, and efficient palladium-, copper-, ligand-, and amine-free Sonogashira-type cross-coupling reaction of terminal alkynes with unreactive aryl fluorides in the presence of sodium, sodium methoxide, and calcium hydroxide under the assistance of a Grignard reagent was developed. A plausible mechanism was also suggested.
