168134-74-5

Upstream product

• 168134-73-4 (R)-3-((S)-2-Benzyloxymethyl-3-phenyl-propionyl)-4-isopropyl-oxazolidin-2-one 
• 96837-44-4 (R)-4-isopropyl-3-(3-phenylpropanoyl)oxazolidin-2-one 
• 108-24-7 acetic anhydride 
• 207444-45-9 (R)-3-((S)-2-Hydroxymethyl-3-phenyl-propionyl)-4-isopropyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Asymmetric synthesis of A-factor

The synthesis of enantlopure A-factor ['autoregulatory factor'; (3R)-(-)-2-(6-methylheptanoyl)-3-hydroxymethylbutano-4-lactone] by the completely diastereoselective benzyloxymethylation of (4R)-3-(3-phenylpropanoyl)-4-isopropyloxazolidin-2-one is reported.

A convenient synthesis of enantiopure paraconic acid- A key intermediate in the synthesis of A-factor

Enantiopure (S)-(-)-paraconic acid 2 has been synthesised by the stereospecific benzyloxymethylation of a titanium enolate derived from a homochiral oxazolidinone and dihydrocinnamoyl chloride.