168135-07-7

Upstream product

• 37614-58-7 3-(4-bromophenyl)prop-2-yn-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 33458-10-5 1-bromo-4-(1,2-dibromoethyl)benzene 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 766-96-1 4-bromo-1-ethynylbenzene 

Downstream Products

• 168135-08-8 methyl-3-<3-<4-(3-t-butyldimethylsilylether-1-propynyl)phenoxy>-4-methoxyphenyl> propionate 
• 143551-94-4 (Z)-3-<3-<4-(3-hydroxy-1-propenyl)phenoxy>-4-methoxyphenyl> propionic acid 
• 143551-93-3 methyl (Z)-3-<3-<4-(3-hydroxy-1-propenyl)phenoxy>-4-methoxyphenyl> propionate 
• 168135-09-9 methyl (Z)-3-<3-<4-(3-t-butyldimethylsilylether-1-propenyl)phenoxy>-4-methoxyphenyl> propionate 

Relevant academic research and scientific papers

An Ullmann ether reaction involving an alkynyl substrate: A convergent route to a combretastatin intermediate

We found that we could employ a disubstituted alkynyl halide in an Ullmann ether reaction to produce the cis-alkene intermediate 3 of the combretastatin natural products.