168144-41-0

Basic information

• Product Name: 1-(diphenylmethyl)-3-methoxy-3-methylazetidine
• Synonyms: 1-(diphenylmethyl)-3-methoxy-3-methylazetidine
• CAS NO: 168144-41-0
• Molecular Weight: 267.371
• Mol File: 168144-41-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(diphenylmethyl)-3-methoxy-3-methylazetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(diphenylmethyl)-3-methoxy-3-methylazetidine(168144-41-0)
• EPA Substance Registry System: 1-(diphenylmethyl)-3-methoxy-3-methylazetidine(168144-41-0)

Safety Data

• Hazardous Substances Data: 168144-41-0(Hazardous Substances Data)

Usage

Chemical structure

1-(diphenylmethyl)-3-methoxy-3-methylazetidine is a complex chemical compound with a diphenylmethyl group, a methoxy group, and a methylazetidine ring.

Diphenylmethyl group

This group consists of two phenyl rings attached to a central carbon atom.

Methoxy group

This group is composed of a single oxygen atom bonded to a methyl group.

Methylazetidine ring

A five-membered heterocyclic ring containing both carbon and nitrogen atoms.

Potential applications

The compound has potential applications in organic synthesis, pharmaceuticals, and materials science.

Building block

It could be used as a building block for the synthesis of more complex molecules.

Unique structure

The compound has a unique structure due to its complex arrangement of functional groups.

Diverse functional groups

The presence of diphenylmethyl, methoxy, and methylazetidine groups makes it an interesting target for chemical research and development.

Upstream product

• 40320-63-6 1-benzhydryl-3-methylazetidin-3-ol 
• 74-88-4 methyl iodide 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 40320-60-3 N-benzhydryl 3-azetidinone 

Downstream Products

• 877665-31-1 3-methoxy-3-methylazetidine 
• 942307-80-4 1-(Tert-butoxycarbonyl)-3-methoxy-3-methylazetidine 

Relevant articles and documents

VLA-4 INHIBITORY DRUG

There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally. A compound represented by the following formula (I): wherein R1 represents a hydrogen atom or a C1-8 alkyl group; R2 represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group, orabenzyloxygroupwhichmaybe substituted; Q represents a monocyclic or bicyclic nitrogen-containing heterocyclic group which may be substituted, and has a nitrogen atom as the bonding site; Y represents an oxygen atom or CH2; W represents a bicyclic aromatic hydrocarbon ring group which may be substituted, or a bicyclic aromatic heterocyclic group whichmaybe substituted; R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group; and A1 represents a nitrogen atom or C-R3d (wherein R3d represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group), or a salt thereof, or a VLA-4 inhibitory drug comprising the compound or the salt as an active ingredient.

Synthesis of substituted 5-aminomethyl tetrahydro-isoquinolines and dihydro-isoindoles

The synthesis of ten substituted aminomethylene tetrahydro-isoquinolines is described, proceeding in eight steps from 5-hydroxyisoquinoline via reductive amination of N-Boc tetrahydro-isoquinoline 5-carboxaldehyde. Likewise, reductive amination was used to prepare four substituted dihydro-isoindoles from the corresponding aldehyde. The dihydro-isoindole ring system was conveniently accessed via a 2+2+2 cycloaddition reaction.

A Comvenient Synthesis of 3-Alkoxyazetidines

N-(Alkylidene or arylidene)-2-substituted-2-propenylamines were regiospecifically functionalized into novel N-(alkylidene or arylidene)-2-alkoxy-3-bromo-2-substituted-propylamines, which were proven to be excellent sources for 3-alkoxyazetidines through s