168150-96-7

Basic information

• Product Name: 4-benzyl-2-chloropyrimidine
• Synonyms: 4-benzyl-2-chloropyrimidine
• CAS NO: 168150-96-7
• Molecular Weight: 204.659
• Mol File: 168150-96-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl-2-chloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-2-chloropyrimidine(168150-96-7)
• EPA Substance Registry System: 4-benzyl-2-chloropyrimidine(168150-96-7)

Safety Data

• Hazardous Substances Data: 168150-96-7(Hazardous Substances Data)

Upstream product

• 796095-89-1 4‐benzyl‐2,6-dichloropyrimidine 
• 3934-20-1 2,6-Dichloropyrimidine 
• 62673-31-8 benzyl(bromo)zinc 

Downstream Products

• 1185013-55-1 (4-benzyl-pyrimidin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine 

Relevant articles and documents

Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen

The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP-MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit.