168154-47-0Relevant academic research and scientific papers
Inhibition of nNOS activity in rat brain by synthetic kynurenines: Structure - Activity dependence
Camacho, Encarnación,León, Josefa,Carrión, Adoración,Entrena, Antonio,Escames, Germaine,Khaldy, Huda,Acu?a-Castroviejo, Darío,Gallo, Miguel A.,Espinosa, Antonio
, p. 263 - 274 (2007/10/03)
The overstimulation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors is involved in excitotoxicity, a process participating in neurodegeneration that characterizes some neurological disorders and acute cerebral insults. In looking for com
2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES
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, (2008/06/13)
Use in the prevention and/or in the treatment of neurodegenerative diseases of 2-amino-4-phenyl-4-oxo-butyric acid derivatives which act as kynureninase enzyme inhibitors and/or kynurenine-3-hydroxylase enzyme inhibitors. Several of these derivatives are new and, as such, constitute a further object of this invention, together with the process for their preparation and the pharmaceutical compositions containing them.
