168154-77-6

Basic information

• Product Name: (R)-2-amino-4-oxo-4-phenyl-butyric acid.HCl
• Synonyms: (R)-2-amino-4-oxo-4-phenyl-butyric acid.HCl
• CAS NO: 168154-77-6
• Molecular Weight: 229.663
• Mol File: 168154-77-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-amino-4-oxo-4-phenyl-butyric acid.HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-amino-4-oxo-4-phenyl-butyric acid.HCl(168154-77-6)
• EPA Substance Registry System: (R)-2-amino-4-oxo-4-phenyl-butyric acid.HCl(168154-77-6)

Safety Data

• Hazardous Substances Data: 168154-77-6(Hazardous Substances Data)

Upstream product

• 1379537-13-9 C₁₇H₂₅NO₄S 

Downstream Products

• 384835-42-1 (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylprop-1-yl)dodecanamide 
• 399041-11-3 (2R)-2-dodecanoylamino-4-oxo-4-phenylbutyric acid ethyl ester hydrochloride 
• 383418-30-2 (1R,3S)-dodecanoic acid (3-hydroxy-1-hydroxymethyl-3-phenylpropyl)amide 

Relevant articles and documents

A highly diastereoselective decarboxylative mannich reaction of β-keto acids with optically active N-sulfinyl α-imino esters

A range of protected γ-oxo-α-amino esters have been prepared in a highly regio- and stereoselective manner through the decarboxylative Mannich reaction of β-keto acids with optically active N-tert-butanesulfinyl α-imino esters in the presence of 3 mol % La(OTf)3 or 5 mol % Y(OTf)3 at 20 °C. Preliminary mechanistic studies indicate that the reaction proceeds through imine addition followed by decarboxylation.