168154-77-6

Upstream product

• 1379537-13-9 C₁₇H₂₅NO₄S 

Downstream Products

• 383418-30-2 (1R,3S)-dodecanoic acid (3-hydroxy-1-hydroxymethyl-3-phenylpropyl)amide 
• 399041-11-3 (2R)-2-dodecanoylamino-4-oxo-4-phenylbutyric acid ethyl ester hydrochloride 
• 384835-42-1 (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylprop-1-yl)dodecanamide 

Relevant academic research and scientific papers

A highly diastereoselective decarboxylative mannich reaction of β-keto acids with optically active N-sulfinyl α-imino esters

A range of protected γ-oxo-α-amino esters have been prepared in a highly regio- and stereoselective manner through the decarboxylative Mannich reaction of β-keto acids with optically active N-tert-butanesulfinyl α-imino esters in the presence of 3 mol % La(OTf)3 or 5 mol % Y(OTf)3 at 20 °C. Preliminary mechanistic studies indicate that the reaction proceeds through imine addition followed by decarboxylation.

2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES

Use in the prevention and/or in the treatment of neurodegenerative diseases of 2-amino-4-phenyl-4-oxo-butyric acid derivatives which act as kynureninase enzyme inhibitors and/or kynurenine-3-hydroxylase enzyme inhibitors. Several of these derivatives are new and, as such, constitute a further object of this invention, together with the process for their preparation and the pharmaceutical compositions containing them.