16816-86-7

Upstream product

• 52867-26-2 4-chloro-N-sulfinyl-benzenesulfonamide 
• 2782-91-4 1,1,3,3-tetramethyl-2-thiourea 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 94790-37-1 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 
• 632-22-4 tetramethylurea 

Relevant academic research and scientific papers

Facile one-pot synthesis of tetrasubstituted N-sulfonylguanidines from sulfonamides and ureas

A facile method for the synthesis of tetrasubstituted N-sulfonylguanidines has been developed via the direct condensation of sulfonamides and ureas in the presence of phosphoryl chloride under basic conditions. Detailed synthetic studies showed that this is a simple protocol for preparing N-sulfonylguanidines at room temperature in a short reaction time with good to excellent yields. Graphic abstract: [Figure not available: see fulltext.].

Efficient synthesis of tetramethylsulfonylguanidines between a free sulfonamide group and HBTU

The reaction of a sulfonamide moiety with HBTU (O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate) during amide coupling, leading to the formation of tetramethylsulfonylguanidines, is described. Optimised conditions showed that HBT