1682-39-9

Basic information

• Product Name: 5-Fluorobenzoxazol-2-amine
• Synonyms: 5-Fluorobenzoxazol-2-amine;Benzoxazole, 2-amino-5-fluoro-;Nsc24983;Wln: T56 bn doj cz hf;2-Amino-5-fluorobenzoxazole;5-fluoro-1,3-benzoxazol-2-amine(SALTDATA: FREE);5-fluoro-1,3-benzoxazol-2-amine;5-Fluorobenzo[d]oxazol-2-amine
• CAS NO: 1682-39-9
• Molecular Formula: C7H5FN2O
• Molecular Weight: 152.13
• Mol File: 1682-39-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 282.8°Cat760mmHg
• Flash Point: 124.9°C
• Appearance: /
• Density: 1.3259 (estimate)
• Vapor Pressure: 0.00328mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 5-Fluorobenzoxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluorobenzoxazol-2-amine(1682-39-9)
• EPA Substance Registry System: 5-Fluorobenzoxazol-2-amine(1682-39-9)

Safety Data

• Hazardous Substances Data: 1682-39-9(Hazardous Substances Data)

Usage

General Description

5-Fluorobenzoxazol-2-amine is a chemical compound with the molecular formula C7H5FN2O. It is a derivative of benzoxazole and contains a fluorine atom attached to the benzene ring. 5-Fluorobenzoxazol-2-amine has potential biological activities and is used in pharmaceutical research as a building block for the synthesis of various organic molecules. Its structure and properties make it a valuable tool for the development of new drugs and biologically active compounds. 5-Fluorobenzoxazol-2-amine is important for the study of structure-activity relationships in medicinal chemistry and has the potential to be used in the treatment of various diseases.

InChI:InChI=1/C7H5FN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10)

Upstream product

• 399-97-3 2-amino-4-fluorophenol 
• 271793-71-6 4-fluoro(2-pyrimidinyloxy)benzene 
• 371-41-5 4-Fluorophenol 
• 506-68-3 bromocyane 

Relevant articles and documents

Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB

N-(5-Chlorobenzo[d]oxazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamideox-amide has been identified as a potent inhibitor of Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 0.42 μM. In this study, a series of substituted 2-acylamide-1,3-zole analogues were designed and synthesized, and their anti-Mtb activities were analyzed. In total, 17 compounds were found to be potent anti-Mtb agents, especially against the MDR- and XDR-MTB strains, with MIC values 10 μM. These analogues can inhibit both drug-sensitive and drug-resistant Mtb. Four representative compounds were selected for further profiling, and the results indicate that compound 18 is acceptably safe and has favorable pharmacokinetic (PK) properties. In addition, this compound displays potent activity against Gram-positive bacteria, with MIC values in the range of 1.48–11.86 μM. The data obtained herein suggest that promising anti-Mtb candidates may be developed via structural modification, and that further research is needed to explore other compounds.

Substituted benzo - 1, 3 - [...] compound, its preparation and use

The invention relates to a substituted benzo-1, 3-miscellaneous azole compound shown in the general formula I, and further relates to a preparation method of the compound and application to the preparation of antituberculosis drugs. The compound provided by the invention has effect not only on mycobacterium tuberculosis sensitive strains, but also on resistant strains which have drug resistance to isoniazid, rifampicin, and other traditional frontline antituberculosis drugs, and is a novel antimycobacterium tuberculosis compound.