168210-19-3Relevant academic research and scientific papers
Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity
Colotta, V.,Cecchi, L.,Catarzi, D.,Filacchioni, G.,Martini, C.,et al.
, p. 133 - 139 (2007/10/02)
The syntheses, A%1 and A2a adenosine receptor affinities and structure-activity relationships of some 2-aryl-1,2,4-triazoloquinoxalines, 2-arylimidazoquinoxalines, 1-arylimidazoquinoxalines are reported and compared with that of a previously reported 2-phenylpyrazoloquinoxaline.The results show that some triazoloquinoxalines are potent and specific A1 adenosine receptor ligands and that the replacement of either nitrogen at position 1 or 3 of the triazoloquinoxaline moiety with a CH brought about a decrease in affinity at both adenosine receptors. adenosine receptor ligand / 1,2,4-triazoloquinoxaline / imidazoquinoxaline / imidazoquinoxaline / tricyclic heteroaromatic system
