168253-65-4

Upstream product

• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 
• 820225-71-6 2-phenylcyclohexyl 2-(4-fluorophenyl)glyoxylate 
• 34281-92-0 (1S,2R)-trans-2-phenyl-1-cyclohexanol 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 

Downstream Products

• 168125-51-7 (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol 
• 168125-50-6 (+)-2-(4-fluorophenyl)-3-trimethylsilylpropan-1,2-diol 

Relevant academic research and scientific papers

Synthesis and fungicidal activity of enantiomerically pure (R)- and (S)-silicon-containing azole fungicides

Enantiomerically pure (R)- and (S)-1-(1H-1,2,4-triazol-1-yl)-2-(4- fluorophenyl)-3-trimethylsilylpropan-2-ol 1 were prepared via an enantioselective Grignard reaction. The absolute stereochemistry of 1 was determined by X-ray analysis. In a comparison of in vitro antifungal activities of the enantiomers, the (-)-enantiomer with the R-absolute configuration was far more potent than the (+)-enantiomer.