168267-80-9Relevant academic research and scientific papers
Discovery of an orally bioavailable NK1 receptor antagonist, (2s,3s)-(2- methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity
Ward,Armour,Bays,Evans,Giblin,Heron,Hubbard,Liang,Middlemiss,Mordaunt,Naylor,Pegg,Vinader,Watson,Bountra,Evans
, p. 4985 - 4992 (2007/10/03)
The antiemetic, pharmacokinetic, and metabolic profile of CP-99,994, a potent NK1 receptor antagonist, has been carefully evaluated. As a result we began a medicinal chemistry program which initially identified a 3-furanyl analogue (6) with imp
